| GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. | GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease.
Chown EE, Wang P, Zhao X, Crowder JJ, Strober JW, Sullivan MA, Xue Y, Bennett CS, Perri AM, Evers BM, Roach PJ, Depaoli-Roach AA, Akman HO, Pederson BA, Minassian BA., Free PMC Article | 09/25/2021 |
| An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice. | An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice.
Nitschke S, Chown EE, Zhao X, Gabrielian S, Petković S, Guisso DR, Perri AM, Wang P, Ahonen S, Nitschke F, Minassian BA., Free PMC Article | 08/21/2021 |
| These results demonstrate that pharmacological agents that activate GYS1, the main GS subtype found in skeletal muscle, have potential for use as novel treatments for diabetes that improve glucose metabolism in skeletal muscle. | AJS1669, a novel small-molecule muscle glycogen synthase activator, improves glucose metabolism and reduces body fat mass in mice.
Nakano K, Takeshita S, Kawasaki N, Miyanaga W, Okamatsu Y, Dohi M, Nakagawa T., Free PMC Article | 04/29/2017 |
| We show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity | Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance.
Turnbull J, Tiberia E, Pereira S, Zhao X, Pencea N, Wheeler AL, Yu WQ, Ivovic A, Naranian T, Israelian N, Draginov A, Piliguian M, Frankland PW, Wang P, Ackerley CA, Giacca A, Minassian BA., Free PMC Article | 02/22/2014 |
| Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: glycogen overproduction induces apoptosis in male germ cells. | Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: glycogen overproduction induces apoptosis in male germ cells.
Villarroel-Espíndola F, Maldonado R, Mancilla H, vander Stelt K, Acuña AI, Covarrubias A, López C, Angulo C, Castro MA, Slebe JC, Durán J, García-Rocha M, Guinovart JJ, Concha II. | 11/2/2013 |
| Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1(Nestin-KO) mice. | Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain.
Duran J, Saez I, Gruart A, Guinovart JJ, Delgado-García JM., Free PMC Article | 05/25/2013 |
| Neurodegeneration and functional impairments are associated with glycogen synthase accumulation in the mouse model of Lafora disease. | Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease.
Valles-Ortega J, Duran J, Garcia-Rocha M, Bosch C, Saez I, Pujadas L, Serafin A, Cañas X, Soriano E, Delgado-García JM, Gruart A, Guinovart JJ., Free PMC Article | 02/25/2012 |
| GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1) | Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1.
Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordoñez A, Cuevas Y, Saez-Morales D, Garcia-Bermejo ML, Landazuri MO, Guinovart J, del Peso L., Free PMC Article | 01/15/2011 |
| The endogenous glycogen synthase in extracts from mouse brain bound specifically to SAPK2b/p38b & was phosphorylated at residues Ser644, Ser652, Thr718 and Ser724. | Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.
Kuma Y, Campbell DG, Cuenda A., Free PMC Article | 01/21/2010 |
| Overexpression of glycogen synthase in skeletal muscle results in less branched glycogen. | Overexpression of glycogen synthase in mouse muscle results in less branched glycogen.
Pederson BA, Csitkovits AG, Simon R, Schroeder JM, Wang W, Skurat AV, Roach PJ. | 01/21/2010 |
| JNK signaling regulates the phosphorylation state of several kinases in skeletal muscle. JNK activation is unlikely to be the major mechanism by which contractile activity increases glycogen synthase activity in skeletal muscle. | Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.
Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. | 01/21/2010 |
| In hearts from mPDK1-/- or double GSK3alpha/GSK3beta knockin mice, insulin failed to stimulate the activity of glycogen synthase or induce its dephosphorylation at residues that are phosphorylated by GSK3. | Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart.
Mora A, Sakamoto K, McManus EJ, Alessi DR. | 01/21/2010 |
| the GYS1 gene is not essential for strenuous exercise and has relatively little effect on endurance in mice | Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise.
Pederson BA, Cope CR, Schroeder JM, Smith MW, Irimia JM, Thurberg BL, DePaoli-Roach AA, Roach PJ. | 01/21/2010 |