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    PIGU phosphatidylinositol glycan anchor biosynthesis class U [ Homo sapiens (human) ]

    Gene ID: 128869, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit.

    Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit.
    Liu SS, Jin F, Liu YS, Murakami Y, Sugita Y, Kato T, Gao XD, Kinoshita T, Hattori M, Fujita M., Free PMC Article

    11/22/2021
    PIGU promotes hepatocellular carcinoma progression through activating NF-kappaB pathway and increasing immune escape.

    PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.
    Wei X, Yang W, Zhang F, Cheng F, Rao J, Lu L.

    11/28/2020
    Identification of PIGU as the Hub Gene Associated with KRAS Mutation in Colorectal Cancer by Coexpression Analysis.

    Identification of PIGU as the Hub Gene Associated with KRAS Mutation in Colorectal Cancer by Coexpression Analysis.
    Zhang M, Wang HZ, Li HO, Zhou YJ, Peng RY, Liu J, Zhao Q.

    10/3/2020
    Mutations in PIGU Impair the Function of the glycosylphosphatidylinositol Transamidase Complex, Causing Severe Intellectual Disability, Epilepsy, and Brain Anomalies.

    Mutations in PIGU Impair the Function of the GPI Transamidase Complex, Causing Severe Intellectual Disability, Epilepsy, and Brain Anomalies.
    Knaus A, Kortüm F, Kleefstra T, Stray-Pedersen A, Đukić D, Murakami Y, Gerstner T, van Bokhoven H, Iqbal Z, Horn D, Kinoshita T, Hempel M, Krawitz PM., Free PMC Article

    03/21/2020
    Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z has been described.

    Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z.
    Eisenhaber B, Sinha S, Wong WC, Eisenhaber F., Free PMC Article

    12/7/2019
    our findings suggest that PIGU overexpression provides independent and complementary prognostic information in hepatocellular carcinoma patients

    PIGU overexpression adds value to TNM staging in the prognostic stratification of patients with hepatocellular carcinoma.
    Cao J, Wang P, Chen J, He X.

    11/16/2019
    Low PIG-U expression is associated with Papillary Thyroid Carcinoma.

    Post-translational Regulation of Radioactive Iodine Therapy Response in Papillary Thyroid Carcinoma.
    Amit M, Na'ara S, Francis D, Matanis W, Zolotov S, Eisenhaber B, Eisenhaber F, Weiler Sagie M, Malkin L, Billan S, Charas T, Gil Z.

    02/16/2019
    Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article

    12/5/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Modest association of malignant melanoma with the rs910873 and rs1885120 markers on chromosome 20: a population-based study.
    Debniak T, Gapska P, Serrano-Fernandez P, Rassoud I, Cybulski C, Maleszka R, Sulikowski M, Narod S, Lubiński J.

    09/15/2010
    CDC91L1 is an oncogene in bladder cancer, and implicate the GPI anchoring system as a potential oncogenic pathway and therapeutic target in human cancers

    CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.
    Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B.

    01/21/2010
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