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    CATSPER1 cation channel sperm associated 1 [ Homo sapiens (human) ]

    Gene ID: 117144, updated on 9-Jul-2017

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF.

    Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.
    Williams HL, Mansell S, Alasmari W, Brown SG, Wilson SM, Sutton KA, Miller MR, Lishko PV, Barratt CL, Publicover SJ, Martins da Silva S., Free PMC Article

    09/10/2016
    The role of CATSPER1 in idiopathic asthenospermia pathogenesis: exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk

    Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.
    Shu F, Zhou X, Li F, Lu D, Lei B, Li Q, Yang Y, Yang X, Shi R, Mao X., Free PMC Article

    08/27/2016
    Sox5 and Sox9 cause a significant increase in transactivation of the Catsper1 promoter.

    The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
    Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N.

    11/22/2014
    Progesterone via CatSper activates the PI3K-AKT pathway required for motility and hyperactivation but not for acrosome reaction.

    Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction.
    Sagare-Patil V, Vernekar M, Galvankar M, Modi D.

    01/4/2014
    The immediate upstream region and the first exon in the human CATSPER1 gene negatively regulate transcriptional activity.

    Molecular cloning and analysis of the Catsper1 gene promoter.
    Mata-Rocha M, Alvarado-Cuevas E, Hernández-Sánchez J, Cerecedo D, Felix R, Hernández-Reyes A, Tesoro-Cruz E, Oviedo N, Mata-Rocha M, Alvarado-Cuevas E, Hernández-Sánchez J, Cerecedo D, Felix R, Hernández-Reyes A, Tesoro-Cruz E, Oviedo N.

    11/2/2013
    This work reports the cloning and characterization of the promoter regions in the human and murine Catsper1 genes. The immediate upstream region and the first exon in the human CATSPER1 gene negatively regulate transcriptional activity. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in mouse testis in vivo.

    Molecular cloning and analysis of the Catsper1 gene promoter.
    Mata-Rocha M, Alvarado-Cuevas E, Hernández-Sánchez J, Cerecedo D, Felix R, Hernández-Reyes A, Tesoro-Cruz E, Oviedo N, Mata-Rocha M, Alvarado-Cuevas E, Hernández-Sánchez J, Cerecedo D, Felix R, Hernández-Reyes A, Tesoro-Cruz E, Oviedo N.

    09/13/2013
    CatSper is indeed the principal Ca2+ channel of human spermatozoa, and that it is strongly potentiated by progesterone.

    Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.
    Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV., Free PMC Article

    06/29/2013
    CatSper activation can elicit functionally different behaviors according to the sensitivity of the Ca(2+) store, which may be regulated by capacitation and NO from the cumulus.

    Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm.
    Alasmari W, Costello S, Correia J, Oxenham SK, Morris J, Fernandes L, Ramalho-Santos J, Kirkman-Brown J, Michelangeli F, Publicover S, Barratt CL., Free PMC Article

    05/11/2013
    It was shown that odorants directly activate CatSper without involving G protein-coupled receptors and cAMP. Membrane-permeable analogues of cyclic nucleotides activated CatSper directly via an extracellular site.

    The CatSper channel: a polymodal chemosensor in human sperm.
    Brenker C, Goodwin N, Weyand I, Kashikar ND, Naruse M, Krähling M, Müller A, Kaupp UB, Strünker T., Free PMC Article

    06/9/2012
    The decreased or abnormal expression of the CatSper1 protein may be a factor involved in the pathogenesis of idiopathic asthenozoospermia.

    [CatSper1 protein and idiopathic asthenozoospermia].
    Wu WB, Li YS, Feng XX, Wang QX, Gao XM, Yang XF, Pan ZH, Sun L.

    11/19/2011
    human CatSper is synergistically activated by elevation of intracellular pH and extracellular progesterone

    Progesterone activates the principal Ca2+ channel of human sperm.
    Lishko PV, Botchkina IL, Kirichok Y.

    04/9/2011
    progesterone activates the sperm-specific, pH-sensitive CatSper Ca(2+) channel

    The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.
    Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB.

    04/9/2011
    Studies indicate that CATSPER channel represents a novel human male fertility factor.

    Genetic male infertility and mutation of CATSPER ion channels.
    Hildebrand MS, Avenarius MR, Fellous M, Zhang Y, Meyer NC, Auer J, Serres C, Kahrizi K, Najmabadi H, Beckmann JS, Smith RJ., Free PMC Article

    03/5/2011
    CatSper1 may be a potential target for immunocontraception, and the antibody may be a tool to study the function of ion channels in sperm.

    Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region.
    Li H, Ding X, Guan H, Xiong C.

    01/21/2010
    sequence analysis of CATSPER1 in heritable forms of nonsyndromic male infertility revealed two separate insertion mutations (c.539-540insT and c.948-949insATGGC) that are predicted to lead to frameshifts and premature stop codons

    Human male infertility caused by mutations in the CATSPER1 channel protein.
    Avenarius MR, Hildebrand MS, Zhang Y, Meyer NC, Smith LL, Kahrizi K, Najmabadi H, Smith RJ., Free PMC Article

    01/21/2010
    CATSPER1 is meiotically and post-meiotically expressed in human testis tissue.

    The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa.
    Li HG, Liao AH, Ding XF, Zhou H, Xiong CL.

    01/21/2010
    CatSper1 and CatSper2 can associate with and modulate the function of the Ca(v)3.3 channel, which might be important in the regulation of sperm function.

    Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.
    Zhang D, Chen J, Saraf A, Cassar S, Han P, Rogers JC, Brioni JD, Sullivan JP, Gopalakrishnan M.

    01/21/2010
    Potential role for CatSper in sperm motility and fertility in mouse and human. CatSper is therefore implicated as a potential target to explore the molecular mechanisms of male infertility.

    CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility.
    Nikpoor P, Mowla SJ, Movahedin M, Ziaee SA, Tiraihi T.

    01/21/2010
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