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    MALT1 MALT1 paracaspase [ Homo sapiens (human) ]

    Gene ID: 10892, updated on 11-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.

    Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
    Kondreddy V, Banerjee R, Devi BLAP, Muralidharan K, Piramanayagam S., Free PMC Article

    03/28/2024
    Long-term monitoring of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.

    Long-term monitoring of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.
    Iwamuro M, Takenaka R, Miyahara K, Okanoue S, Yoshioka M, Sakaguchi C, Yamamoto K, Kawai Y, Toyokawa T, Tanaka T, Otsuka M., Free PMC Article

    03/4/2024
    The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.

    The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.
    Maghe C, Trillet K, André-Grégoire G, Kerhervé M, Merlet L, Jacobs KA, Schauer K, Bidère N, Gavard J.

    02/5/2024
    Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas.

    Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas.
    Wimberger N, Ober F, Avar G, Grau M, Xu W, Lenz G, Menden MP, Krappmann D., Free PMC Article

    12/15/2023
    Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet beta-cell function in health and metabolic stress: Is there room for MALT1?

    Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?
    Kowluru A.,

    12/6/2023
    Linkage of Blood MALT1 with CD4+ T Cell Subset, Inflammation, Lipid, and Its Potency as a Biomarker for Predicting Major Adverse Cardiovascular Events in Coronary Heart Disease Patients.

    Linkage of Blood MALT1 with CD4+ T Cell Subset, Inflammation, Lipid, and Its Potency as a Biomarker for Predicting Major Adverse Cardiovascular Events in Coronary Heart Disease Patients.
    Zhang L, Li J, Yang Z, Wang S, Liu J, Luan S, Tian G.

    08/30/2023
    Function and targeting of MALT1 paracaspase in cancer.

    Function and targeting of MALT1 paracaspase in cancer.
    O'Neill TJ, Tofaute MJ, Krappmann D.

    05/25/2023
    Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1).

    Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1).
    Yu L, Firatli Y, Elmanfi S, Gürsoy M, Özdemir Kabalak M, Kasnak G, Pussinen P, Bikker FJ, Caglayan F, Firatli E, Gürsoy UK., Free PMC Article

    05/12/2023
    MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth.

    MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth.
    Kurden-Pekmezci A, Cakiroglu E, Eris S, Mazi FA, Coskun-Deniz OS, Dalgic E, Oz O, Senturk S.

    05/8/2023
    Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing.

    Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing.
    Wittner L, Wagener L, Wiese JJ, Stolzer I, Krug SM, Naschberger E, Jackstadt R, Beyaert R, Atreya R, Kühl AA, Sturm G, Gonzalez-Acera M, Patankar JV, Becker C, Siegmund B, Trajanoski Z, Winner B, Neurath MF, Schumann M, Günther C., Free PMC Article

    05/3/2023
    MALT1-dependent cleavage of CYLD promotes NF-kappaB signaling and growth of aggressive B-cell receptor-dependent lymphomas.

    MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas.
    Minderman M, Lantermans HC, Grüneberg LJ, Cillessen SAGM, Bende RJ, van Noesel CJM, Kersten MJ, Pals ST, Spaargaren M., Free PMC Article

    03/22/2023
    The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-beta and NF-kB signaling pathways in cancer cells.

    The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells.
    Mazi FA, Cakiroglu E, Uysal M, Kalyoncu M, Demirci D, Sozeri PYG, Yilmaz GO, Ozhan SE, Senturk S.

    03/15/2023
    Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma.

    Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma.
    Jiang VC, Liu Y, Lian J, Huang S, Jordan A, Cai Q, Lin R, Yan F, McIntosh J, Li Y, Che Y, Chen Z, Vargas J, Badillo M, Bigcal JN, Lee HH, Wang W, Yao Y, Nie L, Flowers CR, Wang M., Free PMC Article

    02/11/2023
    Blood MALT1 deficiency is common and relates to unfavorable induction therapy response and survival profile in acute myeloid leukemia patients.

    Blood MALT1 deficiency is common and relates to unfavorable induction therapy response and survival profile in acute myeloid leukemia patients.
    Geng H, Wang Y, Wang S.

    11/5/2022
    Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL3 domain in solution.

    Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL(3) domain in solution.
    Han X, Levkovets M, Lesovoy D, Sun R, Wallerstein J, Sandalova T, Agback T, Achour A, Agback P, Orekhov VY., Free PMC Article

    10/8/2022
    The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.

    The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.
    Kondreddy V, Keshava S, Das K, Magisetty J, Rao LVM, Pendurthi UR., Free PMC Article

    10/8/2022
    MALT1 regulates Th2 and Th17 differentiation via NF-kappaB and JNK pathways, as well as correlates with disease activity and treatment outcome in rheumatoid arthritis.

    MALT1 regulates Th2 and Th17 differentiation via NF-κB and JNK pathways, as well as correlates with disease activity and treatment outcome in rheumatoid arthritis.
    Wang Q, Wang Y, Liu Q, Chu Y, Mi R, Jiang F, Zhao J, Hu K, Luo R, Feng Y, Lee H, Zhou D, Mi J, Deng R., Free PMC Article

    09/3/2022
    A nucleation barrier spring-loads the CBM signalosome for binary activation.

    A nucleation barrier spring-loads the CBM signalosome for binary activation.
    Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R., Free PMC Article

    08/6/2022
    Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency.

    Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency.
    Sefer AP, Abolhassani H, Ober F, Kayaoglu B, Bilgic Eltan S, Kara A, Erman B, Surucu Yilmaz N, Aydogmus C, Aydemir S, Charbonnier LM, Kolukisa B, Azizi G, Delavari S, Momen T, Aliyeva S, Kendir Demirkol Y, Tekin S, Kiykim A, Baser OF, Cokugras H, Gursel M, Karakoc-Aydiner E, Ozen A, Krappmann D, Chatila TA, Rezaei N, Baris S.

    07/23/2022
    MALT1 positively relates to Th17 cells, inflammation/activity degree, and its decrement along with treatment reflects TNF inhibitor response in ankylosing spondylitis patients.

    MALT1 positively relates to Th17 cells, inflammation/activity degree, and its decrement along with treatment reflects TNF inhibitor response in ankylosing spondylitis patients.
    Yuan J, Xiang L, Wang F, Zhang L, Liu G, Chang X, Zhang A, Tao Y., Free PMC Article

    07/23/2022
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1 in rheumatoid arthritis: Longitudinal change after treatment and correlation with treatment efficacy of tumor necrosis factor inhibitors.

    Mucosa-associated lymphoid tissue lymphoma translocation protein 1 in rheumatoid arthritis: Longitudinal change after treatment and correlation with treatment efficacy of tumor necrosis factor inhibitors.
    Wang F, Liu G, Xiang L, Yuan J, Tao Y, Zhang L, Zhang A, Chang X., Free PMC Article

    06/11/2022
    MALT1 in asthma children: A potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance-mediated inflammation.

    MALT1 in asthma children: A potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance-mediated inflammation.
    Liu L, Gao Y, Si Y, Liu B, Liu X, Li G, Wang R., Free PMC Article

    05/21/2022
    MALT1 Is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer.

    MALT1 Is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer.
    Lee JL, Ekambaram P, Carleton NM, Hu D, Klei LR, Cai Z, Myers MI, Hubel NE, Covic L, Agnihotri S, Krappmann D, Bornancin F, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC., Free PMC Article

    05/7/2022
    Aberrant blood MALT1 and its relevance with multiple organic dysfunctions, T helper cells, inflammation, and mortality risk of sepsis patients.

    Aberrant blood MALT1 and its relevance with multiple organic dysfunctions, T helper cells, inflammation, and mortality risk of sepsis patients.
    Wang Y, Huang Q, He F., Free PMC Article

    04/16/2022
    Blood MALT1, Th1, and Th17 cells are dysregulated, inter-correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome.

    Blood MALT1, Th1, and Th17 cells are dysregulated, inter-correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome.
    Ye Z, Chen L, Fang Y, Zhao L., Free PMC Article

    03/26/2022
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