| Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization. | Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization.
Robaszkiewicz K, Wróbel J, Moraczewska J., Free PMC Article | 12/4/2023 |
| Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode. | Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode.
Kraus J, Russell RW, Kudryashova E, Xu C, Katyal N, Perilla JR, Kudryashov DS, Polenova T., Free PMC Article | 05/14/2022 |
| Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis. | Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis.
Zhang L, Zhang W, Zuo Z, Tang J, Song Y, Cao F, Yu X, Liu S, Cai X. | 03/19/2022 |
| Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype. | Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype.
Rosen SM, Joshi M, Hitt T, Beggs AH, Agrawal PB., Free PMC Article | 08/28/2021 |
| Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation. | Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation.
Pignataro M, Di Rocco G, Lancellotti L, Bernini F, Subramanian K, Castellini E, Bortolotti CA, Malferrari D, Moro D, Valdrè G, Borsari M, Del Monte F., Free PMC Article | 07/10/2021 |
| LncRNA SOX2 overlapping transcript (SOX2-OT) expression was conspicuously elevated in prostate cancer (PC) tissues and cells. Silenced SOX2-OT could repress PC cell proliferation and migration. SOX2-OT bound with miR-369-3p and negatively correlated with miR-369-3p in PC. Cofilin 2 (CFL2) was found to be a downstream target gene of miR-369-3p. | Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis.
Wo Q, Zhang D, Hu L, Lyu J, Xiang F, Zheng W, Shou J, Qi X. | 07/18/2020 |
| These results identify cofilin as a key molecule that may be therapeutically targeted to restore T cell motility necessary for T cell tissue repopulation, immune reconstitution, and immune control of viremia. | Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α(4)β(7) integrin antibody.
He S, Fu Y, Guo J, Spear M, Yang J, Trinité B, Qin C, Fu S, Jiang Y, Zhang Z, Xu J, Ding H, Levy DN, Chen W, Petricoin E 3rd, Liotta LA, Shang H, Wu Y., Free PMC Article | 04/11/2020 |
| severe Congenital myopathies related to novel homozygous or compound heterozygous loss-of-function mutations in CFL2, are reported. | Expanding the histopathological spectrum of CFL2-related myopathies.
Fattori F, Fiorillo C, Rodolico C, Tasca G, Verardo M, Bellacchio E, Pizzi S, Ciolfi A, Fagiolari G, Lupica A, Broda P, Pedemonte M, Moggio M, Bruno C, Tartaglia M, Bertini E, D'Amico A. | 12/7/2019 |
| Here we report atomic-level characterization by magic angle spinning (MAS) NMR of the muscle isoform of human cofilin 2 (CFL2) bound to F-actin. We demonstrate that resonance assignments for the majority of atoms are readily accomplished and we derive the intermolecular interface between CFL2 and F-actin. | Structural Analysis of Human Cofilin 2/Filamentous Actin Assemblies: Atomic-Resolution Insights from Magic Angle Spinning NMR Spectroscopy.
Yehl J, Kudryashova E, Reisler E, Kudryashov D, Polenova T., Free PMC Article | 11/10/2018 |
| The secreted levels of the cofilin-2 protein in radioresistant NPC patients were significantly higher than those of radiosensitive cases. | Cofilin-2 Acts as a Marker for Predicting Radiotherapy Response and Is a Potential Therapeutic Target in Nasopharyngeal Carcinoma.
Yu BB, Lin GX, Li L, Qu S, Liang ZG, Chen KH, Zhou L, Lu QT, Sun YC, Zhu XD., Free PMC Article | 09/22/2018 |
| miR-3189-3p mimics enhanced the effects of the S100A4 siRNA on the inhibition of gastric cancer cell proliferation and migration by targeting CFL2. | miR-3189-3p Mimics Enhance the Effects of S100A4 siRNA on the Inhibition of Proliferation and Migration of Gastric Cancer Cells by Targeting CFL2.
Bian Y, Guo J, Qiao L, Sun X., Free PMC Article | 08/4/2018 |
| The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer. | Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer.
Osip'yants AI, Knyazev EN, Galatenko AV, Nyushko KM, Galatenko VV, Shkurnikov MY, Alekseev BY. | 02/18/2017 |
| analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover | TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.
Chin SM, Jansen S, Goode BL., Free PMC Article | 09/17/2016 |
| The serum lever of Alzheimer's disease were increase and the expression of clf2 strongly correlated with the Mini-Mental State Examination scores of the AD patients | Translational study of Alzheimer's disease (AD) biomarkers from brain tissues in AβPP/PS1 mice and serum of AD patients.
Sun Y, Rong X, Lu W, Peng Y, Li J, Xu S, Wang L, Wang X. | 03/5/2016 |
| In primary tumours, both desmin and CFL2 expression predicted improved overall survival in multivariate analyses | Progressive loss of myogenic differentiation in leiomyosarcoma has prognostic value.
Demicco EG, Boland GM, Brewer Savannah KJ, Lusby K, Young ED, Ingram D, Watson KL, Bailey M, Guo X, Hornick JL, van de Rijn M, Wang WL, Torres KE, Lev D, Lazar AJ., Free PMC Article | 12/19/2015 |
| Cofilin 2 phosphorylation and genetic overexpression plays a role in the pathogenesis of idiopathic dilated cardiomyopthay. | Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy.
Subramanian K, Gianni D, Balla C, Assenza GE, Joshi M, Semigran MJ, Macgillivray TE, Van Eyk JE, Agnetti G, Paolocci N, Bamburg JR, Agrawal PB, Del Monte F., Free PMC Article | 06/20/2015 |
| patients with severe nemaline myopathy should be screened for mutations in CFL2. | Novel cofilin-2 (CFL2) four base pair deletion causing nemaline myopathy.
Ong RW, AlSaman A, Selcen D, Arabshahi A, Yau KS, Ravenscroft G, Duff RM, Atkinson V, Allcock RJ, Laing NG. | 10/4/2014 |
| study investigated the comparison of the levels of cofilin-1 and cofilin-2 in regressive QR-32 and progressive QRsP-11cells by western blotting | Malignant progressive tumor cell clone exhibits significant up-regulation of cofilin-2 and 27-kDa modified form of cofilin-1 compared to regressive clone.
Kuramitsu Y, Wang Y, Okada F, Baron B, Tokuda K, Kitagawa T, Akada J, Nakamura K. | 11/30/2013 |
| Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit. | Biophysics of actin filament severing by cofilin.
Elam WA, Kang H, De la Cruz EM., Free PMC Article | 06/1/2013 |
| A novel homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met) of CFL2 was identified in two siblings with congenital myopathy. | Congenital myopathy caused by a novel missense mutation in the CFL2 gene.
Ockeloen CW, Gilhuis HJ, Pfundt R, Kamsteeg EJ, Agrawal PB, Beggs AH, Dara Hama-Amin A, Diekstra A, Knoers NV, Lammens M, van Alfen N., Free PMC Article | 12/22/2012 |
| cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta | Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Sudnitsyna MV, Seit-Nebi AS, Gusev NB. | 06/23/2012 |
| the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state | Remodeling of actin filaments by ADF/cofilin proteins.
Galkin VE, Orlova A, Kudryashov DS, Solodukhin A, Reisler E, Schröder GF, Egelman EH., Free PMC Article | 03/10/2012 |
| Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues | Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues.
Wang Y, Kuramitsu Y, Ueno T, Suzuki N, Yoshino S, Iizuka N, Zhang X, Oka M, Nakamura K. | 01/28/2012 |
| PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation | Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation.
Vogel S, Wottawa M, Farhat K, Zieseniss A, Schnelle M, Le-Huu S, von Ahlen M, Malz C, Camenisch G, Katschinski DM., Free PMC Article | 11/27/2010 |
| FXa-mediated sustained cofilin inactivation leads to stabilization of actin filaments incompatible with migration | Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
Borensztajn K, Peppelenbosch MP, Spek CA. | 09/27/2010 |