| Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice. | Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
Zhang WW, Cao H, Li Y, Fu XJ, Zhang YQ., Free PMC Article | 03/26/2022 |
| Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis. | Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
Chen T, Zhou Y, Liu X, Liu Y, Yuan J, Wang Z. | 02/5/2022 |
| Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium. | Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
Duffy MP, Sup ME, Guo XE., Free PMC Article | 11/22/2021 |
| Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice. | Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
Liu X, Zhou Y, Yang D, Li S, Liu X, Wang Z. | 05/29/2021 |
| Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons. | Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
Yang J, Qiu L, Strobel M, Kabel A, Zha XM, Chen X., Free PMC Article | 05/22/2021 |
| Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons. | Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
Hu ML, Zhang WW, Cao H, Zhang YQ. | 06/22/2019 |
| Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice. | Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.
Zhang J, Yuan Y, Liu Q, Yang D, Liu M, Shen L, Zhou Y, Wang Z. | 02/4/2017 |
| AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE. | Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
Wang Z, Zhou Y, Luo Y, Zhang J, Zhai Y, Yang D, Zhang Z, Li Y, Storm DR, Ma RZ., Free PMC Article | 09/10/2016 |
| genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose | Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.
Challis RC, Tian H, Yin W, Ma M., Free PMC Article | 07/30/2016 |
| Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse. | Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model.
Ansoleaga B, Garcia-Esparcia P, Llorens F, Moreno J, Aso E, Ferrer I. | 11/7/2015 |
| increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements | A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
Pitman JL, Wheeler MC, Lloyd DJ, Walker JR, Glynne RJ, Gekakis N., Free PMC Article | 10/10/2015 |
| Study identifies the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 as requirements for initiation and stabilization of OR expression. | An epigenetic trap stabilizes singular olfactory receptor expression.
Lyons DB, Allen WE, Goh T, Tsai L, Barnea G, Lomvardas S., Free PMC Article | 10/19/2013 |
| Coexpression of serotonin receptor 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth. | Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.
Guadiana SM, Semple-Rowland S, Daroszewski D, Madorsky I, Breunig JJ, Mykytyn K, Sarkisian MR., Free PMC Article | 04/6/2013 |
| Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo. | The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.
Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO., Free PMC Article | 02/16/2013 |
| We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing. | Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase.
Chen X, Xia Z, Storm DR., Free PMC Article | 01/26/2013 |
| In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium. | Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice.
Ma X, Peterson R, Turnbull J., Free PMC Article | 03/24/2012 |
| Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3. | Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase.
Wang Z, Storm DR., Free PMC Article | 12/17/2011 |
| AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning | The type 3 adenylyl cyclase is required for novel object learning and extinction of contextual memory: role of cAMP signaling in primary cilia.
Wang Z, Phan T, Storm DR., Free PMC Article | 06/18/2011 |
| GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct | GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Rao R, Patel S, Hao C, Woodgett J, Harris R., Free PMC Article | 03/29/2010 |
| cAMP signals generated by AC3 in the hypothalamus may play a critical role in regulation of body weight | Adult type 3 adenylyl cyclase-deficient mice are obese.
Wang Z, Li V, Chan GC, Phan T, Nudelman AS, Xia Z, Storm DR., Free PMC Article | 02/8/2010 |
| point to a major role played by a crucial element of the odorant-induced transduction cascade, adenylyl cyclase 3, in the targeting of olfactory sensory neuron axons towards the brain | Adenylyl cyclase-dependent axonal targeting in the olfactory system.
Col JA, Matsuo T, Storm DR, Rodriguez I. | 01/21/2010 |
| required for normal spermatid or spermatozoa function and male fertility | Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function.
Livera G, Xie F, Garcia MA, Jaiswal B, Chen J, Law E, Storm DR, Conti M. | 01/21/2010 |
| adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest | Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
Horner K, Livera G, Hinckley M, Trinh K, Storm D, Conti M. | 01/21/2010 |
| There was robust Adcy3 expression in both olfactory sensory neuron cilia and axons during the period of active glomerular formation in neonatal transgenic mice. | Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice.
Zou DJ, Chesler AT, Le Pichon CE, Kuznetsov A, Pei X, Hwang EL, Firestein S., Free PMC Article | 01/21/2010 |