| PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway. | PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway.
Wang P, Zhang T, Jiang N, Wang K, Feng L, Liu T, Yang X., Free PMC Article | 12/20/2023 |
| Downregulated miR-181a alleviates H2O2-induced oxidative stress and cellular senescence by targeting PDIA6 in human foreskin fibroblasts. | Downregulated miR-181a alleviates H(2)O(2)-induced oxidative stress and cellular senescence by targeting PDIA6 in human foreskin fibroblasts.
Huang Y, Yan H, Yang Y, Zhou J, Xu Q, Meng H., Free PMC Article | 02/11/2023 |
| Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis. | Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis.
Mestre-Farràs N, Guerrero S, Bley N, Rivero E, Coll O, Borràs E, Sabidó E, Indacochea A, Casillas-Serra C, Järvelin AI, Oliva B, Castello A, Hüttelmaier S, Gebauer F., Free PMC Article | 08/20/2022 |
| Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes. | Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes.
Al-Fadhli FM, Afqi M, Sairafi MH, Almuntashri M, Alharby E, Alharbi G, Abdud Samad F, Hashmi JA, Zaytuni D, Bahashwan AA, Choi JH, Peake RWA, Beutler B, Almontashiri NAM. | 04/30/2022 |
| Protein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis. | Protein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis.
Huang Y, He P, Ding J., Free PMC Article | 02/19/2022 |
| PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of beta-catenin and PD-L1. | PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.
Ma Y, Xia P, Wang Z, Xu J, Zhang L, Jiang Y., Free PMC Article | 02/5/2022 |
| PDIA6 contributes to aerobic glycolysis and cancer progression in oral squamous cell carcinoma. | PDIA6 contributes to aerobic glycolysis and cancer progression in oral squamous cell carcinoma.
Mao L, Wu X, Gong Z, Yu M, Huang Z., Free PMC Article | 08/28/2021 |
| One novel transcriptome-wide significant association from this study is the downregulation of PDIA6, which showed minimal evidence of association in the genome-wide association study (GWAS). | Novel Insight Into the Etiology of Autism Spectrum Disorder Gained by Integrating Expression Data With Genome-wide Association Statistics.
Pain O, Pocklington AJ, Holmans PA, Bray NJ, O'Brien HE, Hall LS, Pardiñas AF, O'Donovan MC, Owen MJ, Anney R., Free PMC Article | 07/4/2020 |
| The results of this study suggest that PDIA6 is an important component of EGFR-mediated migration and invasion of U87MG cells. | PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells.
Kim TW, Ryu HH, Li SY, Li CH, Lim SH, Jang WY, Jung S. | 08/31/2019 |
| PDIA6 is overexpressed in NSCLC and inhibits cisplatin-induced NSCLC cell apoptosis and autophagy via the MAP4K1/JNK/c-Jun signaling pathway, suggesting that PDIA6 may serve as a biomarker and therapeutic target for NSCLC patients. | PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway.
Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, Fu H, Pei S, Chen L, Chi X, Zhang L, Zhu X, Song Y, Wang Y, Meng S, Jiang T, Shao S., Free PMC Article | 08/24/2019 |
| The cell surface trafficking of PDIA1, PDIA3, and PDIA6 is dependent on KDELR1, which travels in a dynamic manner to the cell surface. This transport is assumed to result in PDI cell surface association, which differs from PDI inducible secretion into the extracellular space. | KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases.
Bartels AK, Göttert S, Desel C, Schäfer M, Krossa S, Scheidig AJ, Grötzinger J, Lorenzen I. | 04/20/2019 |
| ERp5 triggers fibrinogen dissociation from aIIbb3 integrin. | Mechano-redox control of integrin de-adhesion.
Passam F, Chiu J, Ju L, Pijning A, Jahan Z, Mor-Cohen R, Yeheskel A, Kolšek K, Thärichen L, Aponte-Santamaría C, Gräter F, Hogg PJ., Free PMC Article | 04/13/2019 |
| Study reported for the first time that one of the proteins that binds to P5 in U251 glioblastoma cells is vimentin, and the present findings indicated that P5 may be an attractive target for novel molecular targeted therapy of glioblastoma. | Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target.
Horibe T, Torisawa A, Masuda Y, Kawakami K. | 02/9/2019 |
| Results indicate that protein disulfide isomerase family 6 (PDIA6) overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway. | PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.
Gao H, Sun B, Fu H, Chi X, Wang F, Qi X, Hu J, Shao S., Free PMC Article | 02/3/2018 |
| the chaperone 78-kDa glucose-regulated protein (GRP78) protects the MPD against PDI-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition. | GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.
Schäfer M, Granato DC, Krossa S, Bartels AK, Yokoo S, Düsterhöft S, Koudelka T, Scheidig AJ, Tholey A, Paes Leme AF, Grötzinger J, Lorenzen I. | 11/25/2017 |
| Downregulation of PDIA6 inhibited BC cell proliferation and invasion in vitro as well as tumor growth and metastasis in vivo. In addition, PDIA6 downregulation suppressed the Wnt/beta-catenin signaling pathway. | The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion.
Cheng HP, Liu Q, Li Y, Li XD, Zhu CY., Free PMC Article | 11/4/2017 |
| Results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. | MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone.
Herr I, Sähr H, Zhao Z, Yin L, Omlor G, Lehner B, Fellenberg J. | 10/21/2017 |
| ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head. | Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.
Bromfield EG, McLaughlin EA, Aitken RJ, Nixon B. | 10/22/2016 |
| Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. | Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
Fellenberg J, Sähr H, Kunz P, Zhao Z, Liu L, Tichy D, Herr I. | 05/21/2016 |
| PDIA3 and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer. | PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.
Ramos FS, Serino LT, Carvalho CM, Lima RS, Urban CA, Cavalli IJ, Ribeiro EM. | 03/26/2016 |
| CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 and PDIA6. | The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.
Tufo G, Jones AW, Wang Z, Hamelin J, Tajeddine N, Esposti DD, Martel C, Boursier C, Gallerne C, Migdal C, Lemaire C, Szabadkai G, Lemoine A, Kroemer G, Brenner C., Free PMC Article | 01/24/2015 |
| Txnip is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip increases PDI activity. | Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
Lee S, Min Kim S, Dotimas J, Li L, Feener EP, Baldus S, Myers RB, Chutkow WA, Patwari P, Yoshioka J, Lee RT., Free PMC Article | 01/24/2015 |
| levels of expression of ERp5 and GRP78 correlated with the level of expression of membrane-bound MICA in chronic lymphocytic leukemia patients. | Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.
Huergo-Zapico L, Gonzalez-Rodriguez AP, Contesti J, Gonzalez E, López-Soto A, Fernandez-Guizan A, Acebes-Huerta A, de Los Toyos JR, Lopez-Larrea C, Groh V, Spies T, Gonzalez S. | 10/6/2012 |
| Data show that the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell membrane. | High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Zocchi MR, Catellani S, Canevali P, Tavella S, Garuti A, Villaggio B, Zunino A, Gobbi M, Fraternali-Orcioni G, Kunkl A, Ravetti JL, Boero S, Musso A, Poggi A. | 04/7/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |