NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65. | The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk). Bauer B, Wotapek T, Zöller T, Rutkowski E, Steinle A., Free PMC Article | 06/24/2017 |
Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65 | Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65. Bauer B, Spreu J, Rohe C, Vogler I, Steinle A., Free PMC Article | 07/4/2015 |
structure explains the exceptionally high affinity of the NKp65-KACL interaction compared with other cell-cell interaction pairs, which may compensate for the monomeric nature of NKp65 to achieve cell activation | Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. Li Y, Wang Q, Chen S, Brown PH, Mariuzza RA., Free PMC Article | 10/19/2013 |
Keratinocytes express KACL and are capable of stimulating NKp65-expressing cells in a KACL-dependent manner. | Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Spreu J, Kuttruff S, Stejfova V, Dennehy KM, Schittek B, Steinle A., Free PMC Article | 07/12/2010 |