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    MYH13 myosin heavy chain 13 [ Homo sapiens (human) ]

    Gene ID: 8735, updated on 21-Dec-2019

    Summary

    Official Symbol
    MYH13provided by HGNC
    Official Full Name
    myosin heavy chain 13provided by HGNC
    Primary source
    HGNC:HGNC:7571
    See related
    Ensembl:ENSG00000006788 MIM:603487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MyHC-eo; MyHC-IIL
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See MYH13 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (10300865..10373006, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10201401..10276322, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27a pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 11916 Neighboring gene uncharacterized LOC107985004 Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    muscle myosin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-13
    Names
    extraocular muscle myosin heavy chain
    extraocular myosin heavy chain
    myosin heavy chain, skeletal muscle, extraocular
    myosin heavy chain, skeletal muscle, laryngeal
    myosin, heavy chain 13, skeletal muscle
    myosin, heavy polypeptide 13, skeletal muscle
    superfast myosin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003802.3NP_003793.2  myosin-13

      See identical proteins and their annotated locations for NP_003793.2

      Status: VALIDATED

      Source sequence(s)
      AC005291, AF111782
      Consensus CDS
      CCDS45613.1
      UniProtKB/Swiss-Prot
      Q9UKX3
      Related
      ENSP00000252172.4, ENST00000252172.9
      Conserved Domains (6) summary
      cd14923
      Location:100770
      MYSc_Myh13; class II myosin heavy chain 13, motor domain
      pfam00063
      Location:88770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8501927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:17441837
      TMPIT; TMPIT-like protein
      cl23720
      Location:12731399
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      10300865..10373006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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