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    RPS26B ribosomal 40S subunit protein S26B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856868, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RPS26B
    Gene description
    ribosomal 40S subunit protein S26B
    Primary source
    SGD:S000000933
    Locus tag
    YER131W
    See related
    AllianceGenome:SGD:S000000933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA export from nucleus; and ribosome assembly. Part of 90S preribosome. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to several human genes including RPS26 (ribosomal protein S26). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (423952..424311)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase SAK1 Neighboring gene Com2p Neighboring gene ncRNA Neighboring gene Pmd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosomal Protein Rps26 Influences 80S Ribosome Assembly in Saccharomyces cerevisiae. Belyy A, et al. mSphere, 2016 Jan-Feb. PMID 27303706, Free PMC Article
    2. FLO11 mediated filamentous growth of the yeast Saccharomyces cerevisiae depends on the expression of the ribosomal RPS26 genes. Strittmatter AW, et al. Mol Genet Genomics, 2006 Aug. PMID 16721598
    3. 5´-UTR introns enhance protein expression in the yeast Saccharomyces cerevisiae. Hoshida H, et al. Appl Microbiol Biotechnol, 2017 Jan. PMID 27734122
    4. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Doherty L, et al. Am J Hum Genet, 2010 Feb 12. PMID 20116044, Free PMC Article
    5. Structure of the 80S ribosome-Xrn1 nuclease complex. Tesina P, et al. Nat Struct Mol Biol, 2019 Apr. PMID 30911188

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S26B
    NP_011057.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      423952..424311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179021.1 → NP_011057.1  TPA: ribosomal 40S subunit protein S26B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM37, P39939, Q6B2E8
      UniProtKB/TrEMBL
      A0A6A5Q0E8, A6ZR85, B3LRP6, C7GKX8, C8Z7E8, G2WCZ4, N1P755
      Conserved Domains (1) summary
      pfam01283
      Location:1 → 104
      Ribosomal_S26e; Ribosomal protein S26e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39939.1

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