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    NSA2 rRNA-processing protein NSA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856863, updated on 13-Apr-2024

    Summary

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    Gene symbol
    NSA2
    Gene description
    rRNA-processing protein NSA2
    Primary source
    SGD:S000000928
    Locus tag
    YER126C
    See related
    AllianceGenome:SGD:S000000928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Part of preribosome, large subunit precursor. Orthologous to human NSA2 (NSA2 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (413394..414179, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Dse1p Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene Lcp5p Neighboring gene Vfa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Lebreton A, et al. J Biol Chem, 2006 Sep 15. PMID 16861225
    2. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article
    3. Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly. Micic J, et al. Nat Commun, 2020 Jul 27. PMID 32719344, Free PMC Article
    4. Identification of the binding site of Rlp7 on assembling 60S ribosomal subunits in Saccharomyces cerevisiae. Dembowski JA, et al. RNA, 2013 Dec. PMID 24129494, Free PMC Article
    5. Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling. Barrio-Garcia C, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26619264

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs
      Title: Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-processing protein NSA2
    NP_011052.1
    • Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      413394..414179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179016.1 → NP_011052.1  TPA: rRNA-processing protein NSA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZR80, D3DM32, P40078
      UniProtKB/TrEMBL
      A0A6A5PXG0, B3LRP2, B5VHQ3, C7GKX3, C8Z7E3, G2WCZ9, N1P751
      Conserved Domains (1) summary
      cd11381
      Location:4 → 261
      NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCT_r.1
    6ELZ_r.1
    6EM1_r.1
    6EM5_r.1
    6M62_r.1
    6N8J_r.1
    P40078.1

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