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    RPB11 DNA-directed RNA polymerase II core subunit RPB11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854157, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RPB11
    Gene description
    DNA-directed RNA polymerase II core subunit RPB11
    Primary source
    SGD:S000005365
    Locus tag
    YOL005C
    See related
    AllianceGenome:SGD:S000005365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase II activity and RNA-directed 5'-3' RNA polymerase activity. Involved in termination of RNA polymerase II transcription. Part of RNA polymerase II, core complex. Orthologous to several human genes including POLR2J (RNA polymerase II subunit J). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (315813..316175, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Csi2p Neighboring gene DNA topoisomerase 1 Neighboring gene transcriptional regulator SIN3 Neighboring gene palmitoyltransferase PFA4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. Woychik NA, et al. Gene Expr, 1993. PMID 8508029, Free PMC Article
    2. Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins. Jaag HM, et al. Virology, 2007 Nov 25. PMID 17689583
    3. cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II. Steinmetz EJ, et al. Mol Cell Biol, 2006 Apr. PMID 16537912, Free PMC Article
    4. Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II. Benga WJ, et al. Nucleic Acids Res, 2005. PMID 15987790, Free PMC Article
    5. Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome. Chen X, et al. PLoS Genet, 2017 Jun. PMID 28665995, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An in vitro assay with the tombusvirus replicase indicated that Rpb11p affects TBSV replication and recombination only indirectly, via regulating p33 and p92(pol) levels.
      Title: Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, holoenzyme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II core subunit RPB11
    NP_014638.1
    • RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      315813..316175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183259.1 → NP_014638.1  TPA: DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014638.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W262, P38902
      UniProtKB/TrEMBL
      A0A6A5Q7A1, A6ZNK1, B3LJ51, C7GJV7, C8ZHW0, G2WMM6, N1P2V7
      Conserved Domains (1) summary
      cd06926
      Location:13 → 105
      RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3GTM_K.1
    3RZD_K.1
    3RZO_K.1
    3S14_K.1
    3S2D_K.1
    3S2H_K.1
    4X67_K.1
    4X6A_K.1
    4Y52_K.1
    4Y7N_K.1
    5C3E_K.1
    5C44_K.1
    5C4A_K.1
    5C4J_K.1
    5C4X_K.1
    5OQJ_K.1
    5OQM_K.1
    5OT2_K.1
    5U5Q_K.1
    5VVR_K.1
    5VVS_K.1
    5W4U_K.1
    5W51_K.1
    6BLO_K.1
    6BLP_K.1
    6BM2_K.1
    6BM4_K.1
    6BQF_K.1
    6GYK_K.1
    6GYL_K.1
    6GYM_K.1
    6I84_K.1
    6UPX_K.1
    6UPY_K.1
    6UPZ_K.1
    6UQ0_K.1
    6UQ1_K.1
    6UQ2_K.1
    6UQ3_K.1
    7KED_K.1
    7KEE_K.1
    7KEF_K.1
    7O4I_K.1
    7O4J_K.1
    7O72_K.1
    7O73_K.1
    7O75_K.1
    P38902.1

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