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    HGH1 Hgh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853099, updated on 7-Apr-2024

    Summary

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    Gene symbol
    HGH1
    Gene description
    Hgh1p
    Primary source
    SGD:S000003419
    Locus tag
    YGR187C
    See related
    AllianceGenome:SGD:S000003419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation elongation factor binding activity. Involved in chaperone-mediated protein folding. Located in cytoplasm and nucleus. Orthologous to human HGH1 (HGH1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (870232..871416, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tyrosine--tRNA ligase TYS1 Neighboring gene transcription factor IIF subunit TFG1 Neighboring gene protein kinase BUB1 Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo J, et al. Yeast, 1997 Mar 30. PMID 9133739
    2. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
    3. The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Rodriguez-Peña JM, et al. Yeast, 1998 Jun 30. PMID 9818723
    4. The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Schopf FH, et al. Mol Cell, 2019 Apr 4. PMID 30876805
    5. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Hgh1p
    NP_011703.3
    • Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      870232..871416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181316.3 → NP_011703.3  TPA: Hgh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011703.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUX0, P48362
      UniProtKB/TrEMBL
      A0A6A5PZG0, A6ZUJ8, B3LI48, B5VJC9, C7GVV4, C8Z980, G2WER6, N1P3W7
      Conserved Domains (2) summary
      pfam04063
      Location:99 → 301
      DUF383; Domain of unknown function (DUF383)
      pfam04064
      Location:306 → 360
      DUF384; Domain of unknown function (DUF384)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48362.2

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