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    VHC1 Vhc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852537, updated on 11-Apr-2024

    Summary

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    Gene symbol
    VHC1
    Gene description
    Vhc1p
    Primary source
    SGD:S000000439
    Locus tag
    YBR235W
    See related
    AllianceGenome:SGD:S000000439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables potassium:chloride symporter activity. Involved in potassium ion homeostasis and vacuolar transmembrane transport. Located in vacuole-mitochondrion membrane contact site. Is integral component of vacuolar membrane. Orthologous to human SLC12A9 (solute carrier family 12 member 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (686901..690263)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Dad3p Neighboring gene Arc40p Neighboring gene mRNA (guanine-N7)-methyltransferase Neighboring gene DEAD-box RNA helicase PRP5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast YBR235w gene encodes a homolog of the mammalian electroneutral Na(+)-(K+)-C1- cotransporter family. André B, et al. Biochem Biophys Res Commun, 1995 Dec 5. PMID 8526903
    2. Human NKCC2 cation–Cl– co-transporter complements lack of Vhc1 transporter in yeast vacuolar membranes. Petrezselyova S, et al. Yeast, 2013 Oct. PMID 24251329
    3. Vhc1, a novel transporter belonging to the family of electroneutral cation-Cl(-) cotransporters, participates in the regulation of cation content and morphology of Saccharomyces cerevisiae vacuoles. Petrezselyova S, et al. Biochim Biophys Acta, 2013 Feb. PMID 23022132
    4. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Jensen TH, et al. Mol Cell Biol, 2000 Nov. PMID 11027275, Free PMC Article
    5. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.
      Title: Human NKCC2 cation–Cl– co-transporter complements lack of Vhc1 transporter in yeast vacuolar membranes.
    2. Vhc1 is a novel transporter belonging to the family of electroneutral cation-Cl(-) cotransporters which participates in the regulation of cation content and morphology of Saccharomyces cerevisiae vacuoles
      Title: Vhc1, a novel transporter belonging to the family of electroneutral cation-Cl(-) cotransporters, participates in the regulation of cation content and morphology of Saccharomyces cerevisiae vacuoles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:chloride symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Vhc1p
    NP_009794.3
    • Vacuolar membrane cation-chloride cotransporter (CCC); involved in potassium homeostasis and salt tolerance; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      686901..690263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178583.3 → NP_009794.3  TPA: Vhc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009794.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN1, P38329
      UniProtKB/TrEMBL
      A0A8H4BVD4, A6ZLH4, B3LMS7, B5VEI4, C7GMR8, D3UEY3, G2W9N8
      Conserved Domains (1) summary
      TIGR00930
      Location:45 → 824
      2a30; K-Cl cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38329.1

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