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    FCF1 rRNA-processing protein FCF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851939, updated on 13-Apr-2024

    Summary

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    Gene symbol
    FCF1
    Gene description
    rRNA-processing protein FCF1
    Primary source
    SGD:S000002747
    Locus tag
    YDR339C
    See related
    AllianceGenome:SGD:S000002747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UTP24
    Summary
    Enables endoribonuclease activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human FCF1 (FCF1 rRNA-processing protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1149951..1150520, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRPS28 Neighboring gene uncharacterized protein Neighboring gene tRNA-Ser Neighboring gene arginine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Wells GR, et al. Nucleic Acids Res, 2016 Jun 20. PMID 27034467, Free PMC Article
    2. hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0. Tomecki R, et al. RNA Biol, 2015. PMID 26237581, Free PMC Article
    3. Structural and functional analysis of Utp24, an endonuclease for processing 18S ribosomal RNA. An W, et al. PLoS One, 2018. PMID 29641590, Free PMC Article
    4. 90S pre-ribosome transformation into the primordial 40S subunit. Cheng J, et al. Science, 2020 Sep 18. PMID 32943521
    5. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Utp24 might be the elusive endonuclease that cleaves the pre-rRNA at sites A(1) and/or A(2.)[Utp24]
      Title: The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.
    2. localized to the nucleolus; involved in pre-rRNA processing
      Title: Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-processing protein FCF1
    NP_010626.1
    • PINc domain endonuclease; required for early cleavage of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1149951..1150520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180647.1 → NP_010626.1  TPA: rRNA-processing protein FCF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX1, Q05498
      UniProtKB/TrEMBL
      A0A8H8UNN8, A6ZYU1, B3LFV8, B5VGM2, C7GWN6, C8Z5Q1, G2WB79, N1PAI2
      Conserved Domains (1) summary
      cd09864
      Location:53 → 183
      PIN_Fcf1-like; VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6KE6_5K.1
    6LQP_5K.1
    6LQQ_5K.1
    6LQR_5K.1
    6LQS_5K.1
    6LQT_5K.1
    6LQU_5K.1
    6LQV_5K.1
    6ZQG_UX.1
    Q05498.1

    Gene LinkOut

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