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    Qsox1 quiescin sulfhydryl oxidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84491, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Qsox1provided by RGD
    Official Full Name
    quiescin sulfhydryl oxidase 1provided by RGD
    Primary source
    RGD:68957
    See related
    Ensembl:ENSRNOG00000003649 AllianceGenome:RGD:68957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Qsox; rSOx; Qscn6; Sox-2
    Summary
    Enables FAD binding activity and flavin-linked sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 144.4), Heart (RPKM 82.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70500060..70537711, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67949780..67987434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73423396..73460890, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene deoxyuridine triphosphatase pseudogene Neighboring gene acyl-CoA binding domain containing 6 Neighboring gene 60S ribosomal protein L37-like Neighboring gene LIM homeobox 4 Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The flavo-oxidase QSOX1 supports vascular smooth muscle cell migration and proliferation: Evidence for a role in neointima growth. Borges BE, et al. Biochim Biophys Acta, 2015 Jul. PMID 25766108
    2. Enzyme structure captures four cysteines aligned for disulfide relay. Gat Y, et al. Protein Sci, 2014 Aug. PMID 24888638, Free PMC Article
    3. Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis. Morel C, et al. Exp Cell Res, 2007 Nov 15. PMID 17927979
    4. Expression of SOx-2, a member of the FAD-dependent sulfhydryl oxidase/quiescin Q6 gene family, in rat brain. Mairet-Coello G, et al. Neuroreport, 2002 Nov 15. PMID 12438924
    5. Rat seminal vesicle FAD-dependent sulfhydryl oxidase. Biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin Q6 gene family. Benayoun B, et al. J Biol Chem, 2001 Apr 27. PMID 11278790

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. QSOX1 induces VSMC migration and proliferation in vitro and contributes to neointima thickening in balloon-injured rat carotids.
      Title: The flavo-oxidase QSOX1 supports vascular smooth muscle cell migration and proliferation: Evidence for a role in neointima growth.
    2. RnQSOX1 gives unprecedented insight into the functional group of the cysteine involved in dithiol/disulfide exchange and provides the framework for analysis of the energetics of electron transfer in the flavin adenine dinucleotide cofactor.
      Title: Enzyme structure captures four cysteines aligned for disulfide relay.
    3. The kinetics of QSOX1 expression suggest a more protective effect of QSOX1 rather than an involvement of this protein in apoptosis
      Title: Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis.
    4. The molecular cloning of a new putative brain sulfhydryl oxidase cDNA, rQSOX-L, was reported.
      Title: Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain.
    5. At least two transcripts were detected in brain, suggesting a tissue-specific splicing of its mRNA.
      Title: Expression of SOx-2, a member of the FAD-dependent sulfhydryl oxidase/quiescin Q6 gene family, in rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin-dependent sulfhydryl oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfhydryl oxidase 1
    Names
    FAD-dependent sulfhydryl oxidase-2
    quiescin Q6 sulfhydryl oxidase 1
    rQSOX
    NP_001103368.1
    NP_445883.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109898.1 → NP_001103368.1  sulfhydryl oxidase 1 isoform A precursor

      See identical proteins and their annotated locations for NP_001103368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AB044285, AF217799, AY623665, BM387067
      UniProtKB/Swiss-Prot
      Q6IUU3, Q8K4M2, Q99J80
      Related
      ENSRNOP00000061072.2, ENSRNOT00000068044.4
      Conserved Domains (2) summary
      cd02992
      Location:43 → 155
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:409 → 504
      Evr1_Alr; Erv1 / Alr family

    2. NM_053431.3 → NP_445883.1  sulfhydryl oxidase 1 isoform B precursor

      See identical proteins and their annotated locations for NP_445883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform B which has a shorter, distinct C-terminus when compared to isoform A
      Source sequence(s)
      AB044285, AF217799, BM387067
      UniProtKB/TrEMBL
      A6ICZ2, A6ICZ3
      Related
      ENSRNOP00000005052.6, ENSRNOT00000005052.10
      Conserved Domains (2) summary
      cd02992
      Location:43 → 155
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:409 → 504
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      70500060..70537711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IUU3.1 GenPept UniProtKB/Swiss-Prot:Q6IUU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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