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    PGM3 Phosphoglucomutase/phosphomannomutase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838927, updated on 7-Sep-2023

    Summary

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    Gene symbol
    PGM3
    Gene description
    Phosphoglucomutase/phosphomannomutase family protein
    Primary source
    Araport:AT1G23190
    Locus tag
    AT1G23190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phosphoglucomutase 3; T26J12.5; T26J12_5
    Summary
    Encodes a cytosolic phosphoglucomutase (PGM). Two Arabidopsis PGM proteins (AT1G70730/PGM2 and AT1G23190/PGM3) have high sequence similarities and redundant functions. Mature plants possessing a single cPGM allele had a major reduction in cPGM activity. Whereas pgm2 and pgm3 single mutants are undistinguishable from the wild type, loss of both PGM2 and PGM3 severely impairs male and female gametophyte development.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (8219808..8224547)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Auxin-responsive GH3 family protein Neighboring gene transmembrane protein (Protein of unknown function DUF2359, transmembrane) Neighboring gene ARM repeat superfamily protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene GCK domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of cytosolic phosphoglucomutase compromises gametophyte development in Arabidopsis. Egli B, et al. Plant Physiol, 2010 Dec. PMID 20959421, Free PMC Article
    2. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002
    3. A tandem affinity purification-based technology platform to study the cell cycle interactome in Arabidopsis thaliana. Van Leene J, et al. Mol Cell Proteomics, 2007 Jul. PMID 17426018
    4. High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Koroleva OA, et al. Plant J, 2005 Jan. PMID 15610358
    5. The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes. Singh R, et al. Front Plant Sci, 2020. PMID 32194606, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102167.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gametophyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Phosphoglucomutase/phosphomannomutase family protein
    NP_173732.1
    • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane, chloroplast, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G70730.3); Has 7107 Blast hits to 7096 proteins in 2124 species: Archae - 111; Bacteria - 5258; Metazoa - 510; Fungi - 209; Plants - 166; Viruses - 0; Other Eukaryotes - 853 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8219808..8224547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102167.4 → NP_173732.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49299, Q93Y04, Q9LR42
      UniProtKB/TrEMBL
      A0A178W664, A0A654EHD4
      Conserved Domains (1) summary
      PLN02307
      Location:1 → 583
      PLN02307; phosphoglucomutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49299.2

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