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    MCCA methylcrotonyl-CoA carboxylase alpha chain [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838362, updated on 11-Apr-2024

    Summary

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    Gene symbol
    MCCA
    Gene description
    methylcrotonyl-CoA carboxylase alpha chain
    Primary source
    Araport:AT1G03090
    Locus tag
    AT1G03090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    MCCA is the biotinylated subunit of the dimer MCCase, which is involved in leucine degradation. Both subunits are nuclear coded and the active enzyme is located in the mitochondrion.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (739544..744184)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene BEACH-DOMAIN HOMOLOG A1 Neighboring gene Bax inhibitor-1 family protein Neighboring gene kinase interacting (KIP1-like) family protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Ding G, et al. Plant J, 2012 May. PMID 22211474
    2. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Che P, et al. Plant Physiol, 2002 Jun. PMID 12068107, Free PMC Article
    3. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    4. High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome. Giavalisco P, et al. Plant Mol Biol, 2005 Mar. PMID 15821981
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that mutations in either 3-methylcrotonyl CoA carboxylase MCCA (At1g03090) or MCCB (At4g34030) block mitochondrial Leu catabolism, as inferred from the increased accumulation of Leu.
      Title: Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100191.4
    NM_179252.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion binding HDA PubMed 
    enables methylcrotonoyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methylcrotonyl-CoA carboxylase alpha chain
    NP_563674.1
    • MCCA; FUNCTIONS IN: cobalt ion binding, methylcrotonoyl-CoA carboxylase activity; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, cytosolic ribosome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), PreATP-grasp-like fold (InterPro:IPR016185), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl Co-enzyme a carboxylase biotin carboxylase subunit (TAIR:AT5G35360.1); Has 35200 Blast hits to 30603 proteins in 3073 species: Archae - 603; Bacteria - 22615; Metazoa - 922; Fungi - 892; Plants - 784; Viruses - 0; Other Eukaryotes - 9384 (source: NCBI BLink).
    NP_849583.1
    • MCCA; FUNCTIONS IN: cobalt ion binding, methylcrotonoyl-CoA carboxylase activity; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, cytosolic ribosome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), PreATP-grasp-like fold (InterPro:IPR016185), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl Co-enzyme a carboxylase biotin carboxylase subunit (TAIR:AT5G35360.1); Has 41492 Blast hits to 34824 proteins in 3674 species: Archae - 718; Bacteria - 26555; Metazoa - 1797; Fungi - 1117; Plants - 802; Viruses - 0; Other Eukaryotes - 10503 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      739544..744184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179252.3 → NP_849583.1  methylcrotonyl-CoA carboxylase alpha chain [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42523, Q9SA61
      UniProtKB/TrEMBL
      A0A654E6B5, A0A7G2DQ98
      Conserved Domains (1) summary
      COG4770
      Location:38 → 734
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

    2. NM_100191.4 → NP_563674.1  methylcrotonyl-CoA carboxylase alpha chain [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DQ98
      Conserved Domains (5) summary
      cd06850
      Location:646 → 712
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG4770
      Location:38 → 714
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
      pfam00289
      Location:38 → 146
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02785
      Location:353 → 460
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      cl17255
      Location:151 → 339
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42523.2

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