LAG13 LAG1 longevity assurance-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: LAG13
Gene description: LAG1 longevity assurance-like protein
Primary source: Araport:AT1G13580
Locus tag: AT1G13580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F13B4.7; F13B4_7; LAG One Homologue 3; LAG1 longevity assurance homolog 3; LOH3
Summary: Encodes a ceramide synthase that together with LOH1 is essential for production of ceramides containing Very Long Chain Fatty acid VLCFA-Ceramides(mainly C 22 to 26).
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_001035960.2

NM_001198056.2

NM_101228.2

Function	Evidence Code	Pubs
enables sphingosine N-acyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in endomembrane system organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

NP_001031037.1

LAG1 longevity assurance homolog 3 (LAG13); CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein (TAIR:AT3G25540.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001184985.1

LAG1 longevity assurance homolog 3 (LAG13); CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein (TAIR:AT3G25540.1).

NP_172815.2

LAG1 longevity assurance homolog 3 (LAG13); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein (TAIR:AT3G25540.1); Has 1229 Blast hits to 1229 proteins in 221 species: Archae - 0; Bacteria - 0; Metazoa - 587; Fungi - 304; Plants - 168; Viruses - 3; Other Eukaryotes - 167 (source: NCBI BLink).