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    APK4 adenosine-5'-phosphosulfate (APS) kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836888, updated on 7-Sep-2023

    Summary

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    Gene symbol
    APK4
    Gene description
    adenosine-5'-phosphosulfate (APS) kinase 4
    Primary source
    Araport:AT5G67520
    Locus tag
    AT5G67520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenosine-5'-phosphosulfate (APS) kinase 4; K9I9.8; K9I9_8
    Summary
    Provides activated sulfate for the sulfation of secondary metabolites, including the glucosinolates. Redundant with APK3.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (26939159..26941050)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene succinate dehydrogenase assembly factor Neighboring gene voltage dependent anion channel 2 Neighboring gene Translation protein SH3-like family protein Neighboring gene plant U-box 49 Neighboring gene Arabinanase/levansucrase/invertase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine-5'-phosphosulfate kinase is essential for Arabidopsis viability. Mugford SG, et al. FEBS Lett, 2010 Jan 4. PMID 19903478
    2. Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites. Mugford SG, et al. Plant Cell, 2009 Mar. PMID 19304933, Free PMC Article
    3. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345834.1
    NM_001345835.1
    NM_126152.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male gamete generation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine-5'-phosphosulfate (APS) kinase 4
    NP_569050.1
    • adenosine-5'-phosphosulfate (APS) kinase 4 (APK4); FUNCTIONS IN: kinase activity, transferase activity, transferring phosphorus-containing groups, ATP binding; INVOLVED IN: male gamete generation, sulfate assimilation; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Adenylylsulphate kinase, C-terminal (InterPro:IPR002891); BEST Arabidopsis thaliana protein match is: APS kinase (TAIR:AT2G14750.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26939159..26941050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126152.5 → NP_569050.1  adenosine-5'-phosphosulfate (APS) kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_569050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JF0, Q8LF64, Q9FJX1
      UniProtKB/TrEMBL
      A0A178UDQ3, A0A5S9YID9, A0A654GEX9, A0A7G2FND1
      Conserved Domains (1) summary
      cl17190
      Location:88 → 262
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001345834.1 → NP_001331607.1  adenosine-5'-phosphosulfate (APS) kinase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEE5

    3. NM_001345835.1 → NP_001331608.1  adenosine-5'-phosphosulfate (APS) kinase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEE5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JF0.1

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