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    RMR1 receptor homology region transmembrane domain ring H2 motif protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836748, updated on 11-Apr-2024

    Summary

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    Gene symbol
    RMR1
    Gene description
    receptor homology region transmembrane domain ring H2 motif protein 1
    Primary source
    Araport:AT5G66160
    Locus tag
    AT5G66160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA RECEPTOR HOMOLOGY REGION TRANSMEMBRANE DOMAIN RING H2 MOTIF PROTEIN 1; ATRMR1; JR700; K2A18.24; K2A18_24; receptor homology region transmembrane domain ring H2 motif protein 1; REMEMBR-H2 PROTEIN JR700
    Summary
    Encodes a receptor homology region transmembrane domain, ring H2 motif protein involved in transport of storage proteins to protein storage vacuoles. Co-localizes with DIP positive vesicles.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (26445086..26447433)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RADIATION SENSITIVE 17 Neighboring gene proteasome alpha subunit D2 Neighboring gene Glycosyl hydrolase family 38 protein Neighboring gene sulfurtransferase 18 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ferredoxin-NADP[+]-oxidoreductase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole. Park M, et al. J Cell Biol, 2005 Aug 29. PMID 16115960, Free PMC Article
    2. RMR (Receptor Membrane RING-H2) type 1 and 2 show different promoter activities and subcellular localizations in Arabidopsis thaliana. Occhialini A, et al. Plant Sci, 2018 Jan. PMID 29241571
    3. Dimerization of the Vacuolar Receptors AtRMR1 and -2 from Arabidopsis thaliana Contributes to Their Localization in the trans-Golgi Network. Occhialini A, et al. Int J Mol Sci, 2016 Sep 30. PMID 27706038, Free PMC Article
    4. An Arabidopsis gene regulatory network for secondary cell wall synthesis. Taylor-Teeples M, et al. Nature, 2015 Jan 29. PMID 25533953, Free PMC Article
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The promoter activities of AtRMR1 and AtRMR2 detected in transgenic A. thaliana lines suggest that the expression of these two receptors only partially overlap in some organs and tissues. These results suggest that AtRMR1 and 2 are not functionally redundant, but could also interact and participate in the same cellular process in tissues with an overlapping expression.
      Title: RMR (Receptor Membrane RING-H2) type 1 and 2 show different promoter activities and subcellular localizations in Arabidopsis thaliana.
    2. Data suggest that Arabidopsis thaliana receptor homology region transmembrane domain ring H2 motif protein (AtRMR1) functions as the sorting receptor of phaseolin for its trafficking to the protein storage vacuole [AtRMR1]
      Title: AtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126014.4
    NM_203272.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with trans-Golgi network IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor homology region transmembrane domain ring H2 motif protein 1
    NP_201417.1
    • receptor homology region transmembrane domain ring H2 motif protein 1 (RMR1); FUNCTIONS IN: peptidase activity, zinc ion binding; INVOLVED IN: intracellular protein transport; LOCATED IN: extrinsic to vacuolar membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: Protease-associated (PA) RING/U-box zinc finger family protein (TAIR:AT1G71980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_975001.1
    • receptor homology region transmembrane domain ring H2 motif protein 1 (RMR1); FUNCTIONS IN: peptidase activity, zinc ion binding; INVOLVED IN: intracellular protein transport; LOCATED IN: extrinsic to vacuolar membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: Protease-associated (PA) RING/U-box zinc finger family protein (TAIR:AT1G71980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26445086..26447433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_203272.2 → NP_975001.1  receptor homology region transmembrane domain ring H2 motif protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_975001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YJJ2, A0A654GEK3, F4JZ38
      Conserved Domains (2) summary
      cd00162
      Location:231 → 277
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd02123
      Location:28 → 166
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

    2. NM_126014.4 → NP_201417.1  receptor homology region transmembrane domain ring H2 motif protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M622
      UniProtKB/TrEMBL
      A0A5S9YJJ2, A0A654GEK3
      Conserved Domains (3) summary
      COG5219
      Location:188 → 277
      COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd02123
      Location:28 → 166
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16486
      Location:231 → 274
      mRING-H2-C3H2C2D_ZSWM2; Modified RING finger, H2 subclass (C3H2C2D-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M622.1

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