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    DGK2 diacylglycerol kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836497, updated on 7-Sep-2023

    Summary

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    Gene symbol
    DGK2
    Gene description
    diacylglycerol kinase 2
    Primary source
    Araport:AT5G63770
    Locus tag
    AT5G63770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDGK2; diacylglycerol kinase 2; MBK5.25; MBK5_25
    Summary
    a member of the diacylglycerol kinase gene family. Encodes a functional diacylglycerol kinase. Involved in root elongation and plant development. Gene expression is induced by wounding or cold.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (25518404..25523621)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene NAC domain containing protein 102 Neighboring gene Glycosyl hydrolase family 35 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression. Gómez-Merino FC, et al. J Biol Chem, 2004 Feb 27. PMID 14665624
    2. A Pair of Arabidopsis Diacylglycerol Kinases Essential for Gametogenesis and Endoplasmic Reticulum Phospholipid Metabolism in Leaves and Flowers. Angkawijaya AE, et al. Plant Cell, 2020 Aug. PMID 32471859, Free PMC Article
    3. The hydrophobic segment of Arabidopsis thaliana cluster I diacylglycerol kinases is sufficient to target the proteins to cell membranes. Vaultier MN, et al. FEBS Lett, 2008 May 28. PMID 18466768
    4. Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development. Gómez-Merino FC, et al. J Biol Chem, 2005 Oct 14. PMID 16081412
    5. DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress. Tan WJ, et al. Plant Physiol, 2018 Jul. PMID 29853600, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Pair of Arabidopsis Diacylglycerol Kinases Essential for Gametogenesis and Endoplasmic Reticulum Phospholipid Metabolism in Leaves and Flowers.
      Title: A Pair of Arabidopsis Diacylglycerol Kinases Essential for Gametogenesis and Endoplasmic Reticulum Phospholipid Metabolism in Leaves and Flowers.
    2. DGK2 contributes to phosphatidic acid production by phosphorylating diacylglycerol in the plant response to freezing stress.
      Title: DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress.
    3. DGK1 and DGK2 from cluster I in Arabidopsis thaliana possess amino-terminal hydrophobic segments that are sufficient to address them to endoplasmic reticulum membranes.
      Title: The hydrophobic segment of Arabidopsis thaliana cluster I diacylglycerol kinases is sufficient to target the proteins to cell membranes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345610.1
    NM_125772.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase 2
    NP_001318872.1
    • diacylglycerol kinase 2 (DGK2); CONTAINS InterPro DOMAIN/s: Protein kinase C-like, phorbol ester/diacylglycerol binding (InterPro:IPR002219), Diacylglycerol kinase, catalytic domain (InterPro:IPR001206), Diacylglycerol kinase, accessory domain (InterPro:IPR000756); BEST Arabidopsis thaliana protein match is: diacylglycerol kinase1 (TAIR:AT5G07920.1); Has 2044 Blast hits to 1731 proteins in 371 species: Archae - 0; Bacteria - 465; Metazoa - 1092; Fungi - 0; Plants - 249; Viruses - 0; Other Eukaryotes - 238 (source: NCBI BLink).
    NP_201182.1
    • diacylglycerol kinase 2 (DGK2); FUNCTIONS IN: diacylglycerol kinase activity; INVOLVED IN: response to cold, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, response to wounding, root development, leaf development; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase C-like, phorbol ester/diacylglycerol binding (InterPro:IPR002219), Diacylglycerol kinase, catalytic domain (InterPro:IPR001206), Diacylglycerol kinase, accessory domain (InterPro:IPR000756); BEST Arabidopsis thaliana protein match is: diacylglycerol kinase1 (TAIR:AT5G07920.1); Has 2350 Blast hits to 1757 proteins in 372 species: Archae - 0; Bacteria - 463; Metazoa - 1391; Fungi - 0; Plants - 251; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25518404..25523621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125772.5 → NP_201182.1  diacylglycerol kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRH8, Q9FFN7
      UniProtKB/TrEMBL
      A0A178UJM6, A0A654GEA6
      Conserved Domains (4) summary
      smart00046
      Location:344 → 470
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:146 → 205
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:491 → 648
      DAGK_acc; Diacylglycerol kinase accessory domain
      cl00040
      Location:73 → 133
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001345610.1 → NP_001318872.1  diacylglycerol kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRH8, Q9FFN7
      UniProtKB/TrEMBL
      A0A178UJM6, A0A654GEA6
      Conserved Domains (4) summary
      smart00046
      Location:344 → 470
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:146 → 205
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:491 → 648
      DAGK_acc; Diacylglycerol kinase accessory domain
      cl00040
      Location:73 → 133
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFN7.1

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