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    Fh5 formin homology5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835554, updated on 7-Sep-2023

    Summary

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    Gene symbol
    Fh5
    Gene description
    formin homology5
    Primary source
    Araport:AT5G54650
    Locus tag
    AT5G54650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFH5; FORMIN HOMOLOGY 2 DOMAIN-CONTAINING PROTEIN 5; FORMIN HOMOLOGY 5; formin homology5; MRB17.15; MRB17_15
    Summary
    Encodes a protein with similarity to formins that is involved in cytokinesis. Loss of function mutations exhibit delayed cellularization during endosperm development. FH5 is expressed in the endosperm and the protein localizes to the cell plate. FH5 was shown to be a maternally expressed imprinted gene.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (22197530..22202127, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein-like protein Neighboring gene Histone superfamily protein Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A transmembrane formin nucleates subapical actin assembly and controls tip-focused growth in pollen tubes. Cheung AY, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805480, Free PMC Article
    2. Arabidopsis class I formins control membrane-originated actin polymerization at pollen tube tips. Lan Y, et al. PLoS Genet, 2018 Nov. PMID 30418966, Free PMC Article
    3. Polycomb group-dependent imprinting of the actin regulator AtFH5 regulates morphogenesis in Arabidopsis thaliana. Fitz Gerald JN, et al. Development, 2009 Oct. PMID 19783734
    4. Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis. Ingouff M, et al. Nat Cell Biol, 2005 Apr. PMID 15765105
    5. Profilin promotes formin-mediated actin filament assembly and vesicle transport during polarity formation in pollen. Liu C, et al. Plant Cell, 2021 May 31. PMID 33638636

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Profilin promotes formin-mediated actin filament assembly and vesicle transport during polarity formation in pollen.
      Title: Profilin promotes formin-mediated actin filament assembly and vesicle transport during polarity formation in pollen.
    2. both formin 3 (AtFH3) and formin 5 (AtFH5) are involved in the regulation of apical actin polymerization and actin array construction in pollen tubes, with AtFH3 playing a more dominant role
      Title: Arabidopsis class I formins control membrane-originated actin polymerization at pollen tube tips.
    3. show that a tip-located, the Arabidopsis formin homology5 (FH5), stimulates actin assembly from the subapical membrane, provides actin filaments for vesicular trafficking to the apical dome, and mediates assembly of the subapical actin structure
      Title: A transmembrane formin nucleates subapical actin assembly and controls tip-focused growth in pollen tubes.
    4. AtFH5 is responsible for morphological defects caused by the loss of PcG activity in the seed.
      Title: Polycomb group-dependent imprinting of the actin regulator AtFH5 regulates morphogenesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124846.2
    NM_180860.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in phragmoplast HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    formin homology5
    NP_200276.1
    • formin homology5 (Fh5); CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: Actin-binding FH2 (formin homology 2) family protein (TAIR:AT3G05470.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851191.1
    • formin homology5 (Fh5); CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: Actin-binding FH2 (formin homology 2) family protein (TAIR:AT3G05470.1); Has 73342 Blast hits to 35453 proteins in 1612 species: Archae - 110; Bacteria - 13185; Metazoa - 27017; Fungi - 7334; Plants - 12995; Viruses - 3113; Other Eukaryotes - 9588 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22197530..22202127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180860.2 → NP_851191.1  formin homology5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WPT9, Q6PSU8, Q94B77, Q9FIU0
      UniProtKB/TrEMBL
      A0A5S9YDZ7
      Conserved Domains (1) summary
      pfam02181
      Location:435 → 840
      FH2; Formin Homology 2 Domain

    2. NM_124846.2 → NP_200276.1  formin homology5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WPT9, Q6PSU8, Q94B77, Q9FIU0
      UniProtKB/TrEMBL
      A0A5S9YDZ7
      Conserved Domains (1) summary
      pfam02181
      Location:435 → 840
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94B77.2

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