Timeless timeless circadian regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Timelessprovided by RGD
Official Full Name: timeless circadian regulatorprovided by RGD
Primary source: RGD:620939
See related: Ensembl:ENSRNOG00000031916 AllianceGenome:RGD:620939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tim; rTIM; rTLP
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the Period genes (Per1, Per2, and Per3) and others to downregulate activation of Per1 by Clock/Arntl. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
Expression: Biased expression in Thymus (RPKM 72.0), Spleen (RPKM 62.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1239388..1263344)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (654804..678769)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2643288..2667329)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data presented provide functional evidence that Full-length mammalian Timeless protein (mTIM-fl) is required for expression of suprachiasmatic nucleus circadian rhythmicity
Title: Requirement of mammalian Timeless for circadian rhythmicity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching morphogenesis of an epithelial tube	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bleomycin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bleomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bleomycin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cisplatin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cisplatin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cisplatin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydroxyurea	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroxyurea	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelium	IEP Inferred from Expression Pattern more info	PubMed
involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork arrest	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of replication fork protection complex	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein timeless homolog

Names: timeless circadian clock; timeless homolog; timeless-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031340.2 → NP_112630.2 protein timeless homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q9Z2Y1

Conserved Domains (2) summary

pfam04821
Location:25 → 284

TIMELESS; Timeless protein

pfam05029
Location:1005 → 1091

TIMELESS_C; Timeless protein C terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1239388..1263344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079948.2 → XP_038935876.1 protein timeless homolog isoform X1

UniProtKB/Swiss-Prot

Q9Z2Y1

Conserved Domains (2) summary

pfam04821
Location:25 → 284

TIMELESS; Timeless protein

pfam05029
Location:1005 → 1091

TIMELESS_C; Timeless protein C terminal region
XM_039079950.2 → XP_038935878.1 protein timeless homolog isoform X2

UniProtKB/Swiss-Prot

Q9Z2Y1

UniProtKB/TrEMBL

A0A0G2JY47

Related

ENSRNOP00000070516.2

Conserved Domains (2) summary

pfam04821
Location:25 → 284

TIMELESS; Timeless protein

pfam05029
Location:1005 → 1091

TIMELESS_C; Timeless protein C terminal region
XM_039079954.2 → XP_038935882.1 protein timeless homolog isoform X6

UniProtKB/TrEMBL

A0A8I6GBL8

Related

ENSRNOP00000085093.1

Conserved Domains (2) summary

pfam04821
Location:25 → 284

TIMELESS; Timeless protein

pfam05029
Location:946 → 1032

TIMELESS_C; Timeless protein C terminal region
XM_063264310.1 → XP_063120380.1 protein timeless homolog isoform X6
XM_063264311.1 → XP_063120381.1 protein timeless homolog isoform X7
XM_039079949.2 → XP_038935877.1 protein timeless homolog isoform X1

UniProtKB/Swiss-Prot

Q9Z2Y1

Conserved Domains (2) summary

pfam04821
Location:25 → 284

TIMELESS; Timeless protein

pfam05029
Location:1005 → 1091

TIMELESS_C; Timeless protein C terminal region
XM_063264306.1 → XP_063120376.1 protein timeless homolog isoform X3
XM_063264307.1 → XP_063120377.1 protein timeless homolog isoform X4
XM_063264308.1 → XP_063120378.1 protein timeless homolog isoform X5
XM_063264304.1 → XP_063120374.1 protein timeless homolog isoform X1
XM_063264305.1 → XP_063120375.1 protein timeless homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JY47
XM_063264309.1 → XP_063120379.1 protein timeless homolog isoform X6