ASF1B anti- silencing function 1b [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: ASF1B
Gene description: anti- silencing function 1b
Primary source: Araport:AT5G38110
Locus tag: AT5G38110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: anti- silencing function 1b; F16F17.110; F16F17_110; SGA01; SGA1
Summary: This gene is predicted to encode a silencing group A protein. Plant lines expressing RNAi constructs directed against SGA1 have reduced levels of agrobacterium-mediated root transformation. Its expression is regulated during cell cycle progression through E2F transcription factors.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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This study unravels an important function of AtASF1A/B in plant heat stress response.
Title: Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana.
ASF1A and ASF1B are regulated by cell cycle progression and are involved in DNA repair after UV-B irradiation.
Title: ANTI-SILENCING FUNCTION1 proteins are involved in ultraviolet-induced DNA damage repair and are cell cycle regulated by E2F transcription factors in Arabidopsis.
AtASF1A and AtASF1B proteins bind the histone H3. Simultaneous knockdown impairs chromatin replication and perturbs genome stability and function, causing S-phase and DNA repair checkpoint activation, and abnormal plant growth and development.
Title: Arabidopsis homologues of the histone chaperone ASF1 are crucial for chromatin replication and cell proliferation in plant development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_123171.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-mediated transformation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell size control checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_198627.1

anti- silencing function 1b (ASF1B); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: DNA mediated transformation, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Histone chaperone, ASF1-like (InterPro:IPR006818); BEST Arabidopsis thaliana protein match is: ASF1 like histone chaperone (TAIR:AT1G66740.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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