IMPL2 inositol monophosphatase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: IMPL2
Gene description: inositol monophosphatase family protein
Primary source: Araport:AT4G39120
Locus tag: AT4G39120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: HISN7; HISTIDINE BIOSYNTHESIS 7; myo-inositol monophosphatase like 2; T22F8.20; T22F8_20
Summary: Encodes a chloroplast-localized member of the myo-inositol monophosphatase family, IMPL2 (myo-Inositol monophosphatase like 2) that seems to have multiple enzymatic activities. It contributes to histidine biosynthesis based on it histidinol-phosphate phosphatase activity. In addition, the protein can act as an inositol monophosphatase and an L-galactose-1-phosphate phosphatase in vitro.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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The IMPL2 mutant has an embryo lethal phenotype that could be partially rescued by histidine.
Title: Expression and functions of myo-inositol monophosphatase family genes in seed development of Arabidopsis.
IMPL2 catalyzes the dephosphorylation of histidinol-P to histidinol, completing the His biosynthetic pathway in plants.
Title: The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
IMPL2 encodes a functional histidinol-phosphate phosphatase (HISN7) as evidenced by complementation of a Streptomyces coelicolor hisN mutant and analysis of impl2 T-DNA insertion lines
Title: The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.

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NM_001342523.1

Function	Evidence Code	Pubs
enables L-galactose-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidinol-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histidinol-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISM Inferred from Sequence Model more info

NP_001320164.1

myo-inositol monophosphatase like 2 (IMPL2); FUNCTIONS IN: histidinol-phosphatase activity, 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histidinol-phosphate phosphatase, putative, inositol monophosphatase (InterPro:IPR011809), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: Inositol monophosphatase family protein (TAIR:AT3G02870.1); Has 15134 Blast hits to 15130 proteins in 2267 species: Archae - 157; Bacteria - 8374; Metazoa - 557; Fungi - 304; Plants - 238; Viruses - 0; Other Eukaryotes - 5504 (source: NCBI BLink).

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