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    GBF1 G-box binding factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829826, updated on 15-Feb-2024

    Summary

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    Gene symbol
    GBF1
    Gene description
    G-box binding factor 1
    Primary source
    Araport:AT4G36730
    Locus tag
    AT4G36730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.21; AP22_21; AtGBF1; G-box binding factor 1
    Summary
    member of a gene family encoding basic leucine zipper proteins (GBFs) which bind the G-box
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (17309612..17312488, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene GRAS family transcription factor Neighboring gene ncRNA Neighboring gene HVA22-like protein K Neighboring gene ncRNA Neighboring gene homeobox protein 40 Neighboring gene Quinone reductase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis thaliana. Prasad VB, et al. Mech Dev, 2012 Sep-Dec. PMID 22766018
    2. Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors. Richter S, et al. Nat Cell Biol, 2011 Dec 4. PMID 22138577
    3. The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1. Iglesias-Fernández R, et al. J Exp Bot, 2014 May. PMID 24600022, Free PMC Article
    4. Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development. Maurya JP, et al. Plant J, 2015 Aug. PMID 26047210
    5. Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH. Ram H, et al. Mol Plant, 2014 Feb. PMID 24157608

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis.
      Title: An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis.
    2. This study reveals that MYC2 and GBF1 colocalize and physically interact in the nucleus. This interaction requires the N-terminal domain of each protein.
      Title: Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development.
    3. GBF1 is a transcriptional repressor of the AtCathB3 gene and affects germination kinetics of A. thaliana seeds. As AtCathB3 is also expressed during post-germination in cotyledons, a role for the AtCathB3-like protease in reserve mobilization is inferred.
      Title: The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1.
    4. The DNA binding activity of GBF1 is modulated by heterodimeriation with HY5 and HYH.
      Title: Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH.
    5. Genetic interactions of HY1 and GBF1 in seedling photomorphogenesis.
      Title: HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis thaliana.
    6. the functional interrelations of GBF1 with HY5 and HYH in Arabidopsis seedling development.
      Title: Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana.
    7. In Arabidopsis, GBF1-related exchange factors for the ARF GTPases (ARF GEFs) GNOM and GNL2 play essential roles in polar tip growth of root hairs and pollen, respectively.
      Title: Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors.
    8. GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1
      Title: GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119837.4
    NM_179179.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    G-box binding factor 1
    NP_195391.1
    • G-box binding factor 1 (GBF1); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), G-box binding, MFMR (InterPro:IPR012900), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: basic region/leucine zipper transcription factor 16 (TAIR:AT2G35530.1); Has 3905 Blast hits to 3842 proteins in 356 species: Archae - 8; Bacteria - 123; Metazoa - 1421; Fungi - 442; Plants - 1419; Viruses - 137; Other Eukaryotes - 355 (source: NCBI BLink).
    NP_849510.1
    • G-box binding factor 1 (GBF1); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), G-box binding, MFMR (InterPro:IPR012900), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: basic region/leucine zipper transcription factor 16 (TAIR:AT2G35530.1); Has 3891 Blast hits to 3827 proteins in 347 species: Archae - 8; Bacteria - 109; Metazoa - 1441; Fungi - 440; Plants - 1415; Viruses - 137; Other Eukaryotes - 341 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17309612..17312488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179179.3 → NP_849510.1  G-box binding factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XZX0, A0A7G2F6E6
      Conserved Domains (4) summary
      smart00338
      Location:218 → 282
      BRLZ; basic region leucin zipper
      cd14702
      Location:223 → 274
      bZIP_plant_GBF1; coiled coil [structural motif]
      pfam07777
      Location:1 → 94
      MFMR; G-box binding protein MFMR
      pfam16596
      Location:129 → 209
      MFMR_assoc; Disordered region downstream of MFMR

    2. NM_119837.4 → NP_195391.1  G-box binding factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42774, Q940I9, Q944J1, Q96263
      UniProtKB/TrEMBL
      A0A178V1V9, A0A384KK13, A0A5S9XZX0, Q5K1L6
      Conserved Domains (3) summary
      smart00338
      Location:220 → 284
      BRLZ; basic region leucin zipper
      cd14702
      Location:225 → 276
      bZIP_plant_GBF1; coiled coil [structural motif]
      pfam07777
      Location:1 → 94
      MFMR; G-box binding protein MFMR
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42774.2

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