GLUR2 glutamate receptor 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: GLUR2
Gene description: glutamate receptor 2
Primary source: Araport:AT4G35290
Locus tag: AT4G35290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGLR3.2; ATGLUR2; F23E12.150; F23E12_150; GLR3.2; glutamate receptor 2; GLUTAMATE RECEPTOR 3.2
Summary: Encodes a putative glutamate receptor like-protein, member of Putative ligand-gated ion channel subunit family
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Genomic context

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See GLUR2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 7

Sequence:: Chromosome: 4; NC_003075.7 (16789531..16793685)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
Title: Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
In two genes namely AT2G17260 and AT4G35290, presence of RAV1-A binding site motif in the promoter coupled with results from gene ontology annotation indicate their role in stomatal movement through abscisic acid signaling.
Title: Computational analysis of the glutamate receptor gene family of Arabidopsis thaliana.
Data indicate that in roots, GLR3.4 and GLR3.2 were present primarily in the phloem, especially in the vicinity of the sieve plates, and GLR3.3 was expressed in most cells of the growing primary root but was not enriched in the phloem.
Title: Interacting glutamate receptor-like proteins in Phloem regulate lateral root initiation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001342335.1

Supported by ESTs:

NM_001342336.1

Supported by ESTs:

NM_001342337.1

Supported by ESTs:

NM_001342338.1

Supported by ESTs:

NM_119695.4

Supported by ESTs:

NM_202957.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutamate receptor 2

NP_001320141.1

glutamate receptor 2 (GLUR2); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus, cellular sodium ion homeostasis, cellular potassium ion homeostasis; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: inflorescence meristem, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 2 (TAIR:AT2G17260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_567981.1

glutamate receptor 2 (GLUR2); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus, cellular sodium ion homeostasis, cellular potassium ion homeostasis; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: inflorescence meristem, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 2 (TAIR:AT2G17260.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16789531..16793685

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001342335.1 → NP_001320141.1 glutamate receptor 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O65498, Q93YT1, Q9C561

UniProtKB/TrEMBL

A0A178UST8, A0A5S9XYV3, A0A654FVR0, A0A7G2F3E4

Conserved Domains (3) summary

cd13686
Location:466 → 804

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:31 → 422

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants

pfam00060
Location:590 → 840

Lig_chan; Ligand-gated ion channel
NM_001342336.1 → NP_001329586.1 glutamate receptor 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O65498, Q93YT1, Q9C561

UniProtKB/TrEMBL

A0A178UST8, A0A5S9XYV3, A0A654FVR0, A0A7G2F3E4

Conserved Domains (3) summary

cd13686
Location:466 → 804

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:31 → 422

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants

pfam00060
Location:590 → 840

Lig_chan; Ligand-gated ion channel
NM_001342337.1 → NP_001329588.1 glutamate receptor 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O65498, Q93YT1, Q9C561

UniProtKB/TrEMBL

A0A178UST8, A0A5S9XYV3, A0A654FVR0, A0A7G2F3E4

Conserved Domains (3) summary

cd13686
Location:466 → 804

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:31 → 422

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants

pfam00060
Location:590 → 840

Lig_chan; Ligand-gated ion channel
NM_119695.4 → NP_567981.1 glutamate receptor 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567981.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65498, Q93YT1, Q9C561

UniProtKB/TrEMBL

A0A178UST8, A0A5S9XYV3, A0A654FVR0, A0A7G2F3E4

Conserved Domains (3) summary

cd13686
Location:466 → 804

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:31 → 422

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants

pfam00060
Location:590 → 840

Lig_chan; Ligand-gated ion channel
NM_202957.3 → NP_974686.1 glutamate receptor 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974686.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65498, Q93YT1, Q9C561

UniProtKB/TrEMBL

A0A178UST8, A0A5S9XYV3, A0A654FVR0, A0A7G2F3E4

Conserved Domains (3) summary

cd13686
Location:466 → 804

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:31 → 422

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants

pfam00060
Location:590 → 840

Lig_chan; Ligand-gated ion channel
NM_001342338.1 → NP_001329587.1 glutamate receptor 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UST8, A0A1P8B880, A0A7G2F3E4