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    NAP1;1 nucleosome assembly protein1;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828717, updated on 7-Sep-2023

    Summary

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    Gene symbol
    NAP1;1
    Gene description
    nucleosome assembly protein1;1
    Primary source
    Araport:AT4G26110
    Locus tag
    AT4G26110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NUCLEOSOME ASSEMLY PROTEIN 1;1; ATNAP1;1; F20B18.220; F20B18_220; nucleosome assembly protein1;1
    Summary
    Encodes a member of a small gene family of proteins with similarity to nucleosome assembly proteins.May function in nucleotide excision repair. Loss of function mutations have no obvious visible phenotypes but do seem to affect transcription of NER related genes.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (13232545..13235908)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene MAP kinase/ ERK kinase 1 Neighboring gene Protein phosphatase 2C family protein Neighboring gene ncRNA Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene casein kinase 1 Neighboring gene Ankyrin repeat family protein / BTB/POZ domain-containing protein Neighboring gene cotton fiber protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) regulates cell cycling potentially by cooperating with nucleosome assembly protein AtNAP1;1. Wang Z, et al. BMC Plant Biol, 2018 Jun 1. PMID 29859040, Free PMC Article
    2. Developmentally controlled farnesylation modulates AtNAP1;1 function in cell proliferation and cell expansion during Arabidopsis leaf development. Galichet A, et al. Plant Physiol, 2006 Dec. PMID 17041028, Free PMC Article
    3. An Arabidopsis dual-localized pentatricopeptide repeat protein interacts with nuclear proteins involved in gene expression regulation. Hammani K, et al. Plant Cell, 2011 Feb. PMID 21297037, Free PMC Article
    4. NAP1 family histone chaperones are required for somatic homologous recombination in Arabidopsis. Gao J, et al. Plant Cell, 2012 Apr. PMID 22534127, Free PMC Article
    5. Distinct roles of the histone chaperones NAP1 and NRP and the chromatin-remodeling factor INO80 in somatic homologous recombination in Arabidopsis thaliana. Zhou W, et al. Plant J, 2016 Nov. PMID 27352805

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSN1 was found to function as a positive regulator in cell cycle progression. The interaction between NSN1 and histone chaperone AtNAP1;1, and the high resemblance in sensitivity to genotoxics between nsn1 and atnap1;1 imply the indispensability of the two nuclear proteins for cell cycle regulation.
      Title: Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) regulates cell cycling potentially by cooperating with nucleosome assembly protein AtNAP1;1.
    2. This study highlights distinct functions for different families of histone chaperones in the maintenance of genome stability and establishes a crucial function for NAP1 family histone chaperones in somatic homologous recombination.
      Title: NAP1 family histone chaperones are required for somatic homologous recombination in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125588.2
    NM_118744.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somatic cell DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome assembly protein1;1
    NP_001119060.1
    • nucleosome assembly protein1;1 (NAP1;1); FUNCTIONS IN: DNA binding; INVOLVED IN: DNA repair, nucleosome assembly; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleosome assembly protein (NAP) (InterPro:IPR002164); BEST Arabidopsis thaliana protein match is: nucleosome assembly protein 1;3 (TAIR:AT5G56950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_194341.1
    • nucleosome assembly protein1;1 (NAP1;1); FUNCTIONS IN: DNA binding; INVOLVED IN: DNA repair, nucleosome assembly; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleosome assembly protein (NAP) (InterPro:IPR002164); BEST Arabidopsis thaliana protein match is: nucleosome assembly protein 1;3 (TAIR:AT5G56950.1); Has 21058 Blast hits to 13074 proteins in 728 species: Archae - 43; Bacteria - 905; Metazoa - 8886; Fungi - 3078; Plants - 1413; Viruses - 309; Other Eukaryotes - 6424 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13232545..13235908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125588.2 → NP_001119060.1  nucleosome assembly protein1;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UVZ1, B3H684
      Conserved Domains (1) summary
      pfam00956
      Location:53 → 297
      NAP; Nucleosome assembly protein (NAP)

    2. NM_118744.3 → NP_194341.1  nucleosome assembly protein1;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38809, Q9SZI2
      UniProtKB/TrEMBL
      A0A654FSV9
      Conserved Domains (1) summary
      pfam00956
      Location:53 → 297
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZI2.1

    Gene LinkOut

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