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    AG K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827631, updated on 7-Sep-2023

    Summary

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    Gene symbol
    AG
    Gene description
    K-box region and MADS-box transcription factor family protein
    Primary source
    Araport:AT4G18960
    Locus tag
    AT4G18960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS; AGAMOUS PROTEIN; F13C5.130; F13C5_130
    Summary
    Floral homeotic gene encoding a MADS domain transcription factor. Specifies floral meristem and carpel and stamen identity. Binds CArG box sequences. It is the only C function gene. It interacts genetically with the other homeotic genes to specify the floral organs.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (10382856..10388539)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA ligase/cyclic nucleotide phosphodiesterase family protein Neighboring gene Integrin-linked protein kinase family Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis. Uemura A, et al. Plant Reprod, 2018 Mar. PMID 29218596
    2. Enhanced AGAMOUS expression in the centre of the Arabidopsis flower causes ectopic expression over its outer expression boundaries. Cartolano M, et al. Planta, 2009 Sep. PMID 19554348, Free PMC Article
    3. The second intron of AGAMOUS drives carpel- and stamen-specific expression sufficient to induce complete sterility in Arabidopsis. Liu Z, et al. Plant Cell Rep, 2008 May. PMID 18256838
    4. The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. Ito T, et al. Plant Cell, 2007 Nov. PMID 17981996, Free PMC Article
    5. Transcriptional program controlled by the floral homeotic gene AGAMOUS during early organogenesis. Gómez-Mena C, et al. Development, 2005 Feb. PMID 15634696

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing.
      Title: Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing.
    2. AG-incRNA4 can associate with CLF to repress AG expression in leaf tissues through histone H3 lysine 27methylation 3-mediated repression and to autoregulate its own expression level.
      Title: A noncoding RNA transcribed from the AGAMOUS (AG) second intron binds to CURLY LEAF and represses AG expression in leaves.
    3. SEPALLATA3 and AGAMOUS tetramerization is required for floral meristem determinacy.
      Title: Tetramerization of MADS family transcription factors SEPALLATA3 and AGAMOUS is required for floral meristem determinacy in Arabidopsis.
    4. The feed-forward YUC4 activation by AG and CRC directs a precise change in chromatin state for the shift from floral stem cell maintenance to gynoecium formation.
      Title: Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy.
    5. The expression signals of AG were detected in the initiating carpel primordia and regenerating carpels, and co-localized with those of two Type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs), ARR1 and ARR10.
      Title: Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis.
    6. findings suggest that AGAMOUS functions to maintain the irreversible state of reproductive development through the negative regulation of floral meristem identity genes and genes involved in organ initiation
      Title: Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis.
    7. AP2 does not repress the transcription of AG in the inner two whorls, but instead counteracts AG activity.
      Title: APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
    8. ARF3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy.
      Title: AUXIN RESPONSE FACTOR 3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy.
    9. The ULT1 and LFY pathways act separately in regulating identity and determinacy at the floral meristem. In particular, they independently induce AG expression in the centre of the flower to terminate meristem activity.
      Title: ULTRAPETALA1 and LEAFY pathways function independently in specifying identity and determinacy at the Arabidopsis floral meristem.
    10. FLK and PEP physically interact with proteins involved in AG pre-mRNA processing to secure correct AG function in the floral meristem and flower
      Title: K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001203837.1
    NM_118013.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stamen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_001190766.1
    • AGAMOUS (AG); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: stamen development, maintenance of floral organ identity, leaf development, carpel development; LOCATED IN: endomembrane system, nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT3G58780.3).
    NP_567569.3
    • AGAMOUS (AG); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: stamen development, maintenance of floral organ identity, leaf development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT3G58780.1); Has 7163 Blast hits to 7161 proteins in 920 species: Archae - 0; Bacteria - 2; Metazoa - 633; Fungi - 307; Plants - 6141; Viruses - 0; Other Eukaryotes - 80 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10382856..10388539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341309.1 → NP_001328877.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JSC8

    2. NM_001341310.1 → NP_001328876.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B602

    3. NM_001203837.1 → NP_001190766.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JSC8
      Conserved Domains (1) summary
      pfam01486
      Location:86 → 172
      K-box; K-box region

    4. NM_118013.2 → NP_567569.3  K-box region and MADS-box transcription factor family protein, partial [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567569.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82732, P17839
      Conserved Domains (2) summary
      cd00265
      Location:18 → 91
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:100 → 186
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version

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