GTR1 Major facilitator superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: GTR1
Gene description: Major facilitator superfamily protein
Primary source: Araport:AT3G47960
Locus tag: AT3G47960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtNPF2.10; GLUCOSINOLATE TRANSPORTER-1; NPF2.10; NRT1/ PTR family 2.10
Summary: Encodes a high-affinity, proton-dependent glucosinolate-specific transporter that is crucial for the transport of both methionine- and tryptophan-derived glucosinolates to seeds.
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Genomic context

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Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (17697942..17700923, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucosinolate Transporter1 involves in salt-induced jasmonate signaling and alleviates the repression of lateral root growth by salt in Arabidopsis.
Title: Glucosinolate Transporter1 involves in salt-induced jasmonate signaling and alleviates the repression of lateral root growth by salt in Arabidopsis.
Expression of glucosinolate (GLS) importers GTR1 and GTR2 inside the stele, along with earlier observations, suggest three possible routes of stele-synthesized aliphatic GLS after their synthesis: (i) GTR-dependent import to cells symplastically connected to cortical cells and rhizosphere; (ii) GTR-independent transport via xylem to the shoot; and (iii) GTR-dependent import to GLS-degrading myrosin cells at the cortex.
Title: Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis.
dimerization of GTR1, possibly induced by dephosphorylation of the Thr residue located between the possible transmembrane regions, regulates its plasma membrane localization.
Title: Dimerization of GTR1 regulates their plasma membrane localization.
GTR1 would be involved in the translocation of JA and JA-Ile in plant and may be contributed to correct positioning of JA and JA-Ile to attenuate an excessive wound response in undamaged leaves
Title: GTR1 is a jasmonic acid and jasmonoyl-l-isoleucine transporter in Arabidopsis thaliana.
Phosphorylation of AtGTR1 is not directly involved in regulating AtGTR1 transport activity.
Title: Phosphorylation at serine 52 and 635 does not alter the transport properties of glucosinolate transporter AtGTR1.
GTR1 role of transport processes in leaf glucosinolate distribution
Title: Elucidating the role of transport processes in leaf glucosinolate distribution.
glucosinolate can specifically translocate from rosette and roots to inflorescence in a GTR1- and GTR2-dependent manner
Title: Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots.
GTR1 and GTR2 control the loading of glucosinolates from the apoplasm into the phloem. [GTR1]
Title: NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_114665.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables glucosinolate:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucosinolate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phloem glucosinolate loading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi trans cisterna	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Major facilitator superfamily protein

NP_566896.2

Major facilitator superfamily protein; FUNCTIONS IN: transporter activity; INVOLVED IN: oligopeptide transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT5G62680.1); Has 3941 Blast hits to 3750 proteins in 534 species: Archae - 0; Bacteria - 697; Metazoa - 584; Fungi - 378; Plants - 2186; Viruses - 0; Other Eukaryotes - 96 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17697942..17700923 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114665.4 → NP_566896.2 Major facilitator superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566896.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q944G5, Q94K82, Q9SU59

UniProtKB/TrEMBL

A0A178V6P7, A0A5S9XKH1, A0A7G2EUT7

Conserved Domains (1) summary

cd17416
Location:68 → 605

MFS_NPF1_2; NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters