Gdf10 growth differentiation factor 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdf10provided by RGD
Official Full Name: growth differentiation factor 10provided by RGD
Primary source: RGD:621512
See related: Ensembl:ENSRNOG00000051993 AllianceGenome:RGD:621512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity. Involved in several processes, including osteoblast differentiation; positive regulation of osteoblast differentiation; and regulation of ossification. Located in extracellular space. Orthologous to human GDF10 (growth differentiation factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 23.9), Uterus (RPKM 20.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9243434..9256788)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9237182..9250537)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10250508..10262383)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-beta1/Smad3 signaling pathway.
Title: Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway.
Results suggest that the decreasing growth and differentiation factor 10 may contribute toward neuropathic pain by facilitating N-methyl-D-aspartate receptor activation. Findings shed new light on the understanding of the molecular mechanisms underlying neuropathic pain.
Title: Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation.
findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells
Title: The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.
Gdf10 were present exclusively in the proliferative zone of in growth plate cartilage of 1-week-old rats.
Title: Spatial and temporal regulation of gene expression in the mammalian growth plate.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in ovulation cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transforming growth factor beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth/differentiation factor 10

Names: BIP; BMP-3b; GDF-10; bone morphogenetic protein 3b; bone-inducing protein; prepro bone inducing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024375.1 → NP_077351.1 growth/differentiation factor 10 precursor

See identical proteins and their annotated locations for NP_077351.1

Status: PROVISIONAL

Source sequence(s)

D49494

UniProtKB/Swiss-Prot

P55108

UniProtKB/TrEMBL

A0A0G2JVQ8, A6KFT7

Related

ENSRNOP00000069581.2, ENSRNOT00000081183.2

Conserved Domains (1) summary

pfam00019
Location:372 → 475

TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

9243434..9256788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094852.2 → XP_038950780.1 growth/differentiation factor 10 isoform X1

UniProtKB/TrEMBL

A0A0G2JVQ8

Conserved Domains (1) summary

cd19394
Location:303 → 414

TGF_beta_GDF10; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins