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    Ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 74521, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp4r4provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 4provided by MGI
    Primary source
    MGI:MGI:1921771
    See related
    Ensembl:ENSMUSG00000021209 AllianceGenome:MGI:1921771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1622; 8430415E04Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytoplasm. Predicted to be part of protein serine/threonine phosphatase complex. Predicted to be active in cytosol. Is expressed in early conceptus; secondary oocyte; and telencephalon mantle layer. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 4.9), frontal lobe adult (RPKM 4.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 52.95 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103498509..103580098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103532250..103613839)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871, Free PMC Article
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein serine/threonine phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein serine/threonine phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028980.3 → NP_083256.2  serine/threonine-protein phosphatase 4 regulatory subunit 4

      See identical proteins and their annotated locations for NP_083256.2

      Status: VALIDATED

      Source sequence(s)
      AK029499, BB307572, BC111887
      Consensus CDS
      CCDS36532.1
      UniProtKB/Swiss-Prot
      E9QKU6, Q14CI7, Q14DT1, Q69ZE5, Q8C0Y0, Q9CRR0
      Related
      ENSMUSP00000021631.6, ENSMUST00000021631.12
      Conserved Domains (2) summary
      PTZ00108
      Location:650 → 875
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:214 → 244
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103498509..103580098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244194.4 → XP_011242496.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

      See identical proteins and their annotated locations for XP_011242496.1

      UniProtKB/Swiss-Prot
      Q8C0Y0
      Related
      ENSMUSP00000139786.2, ENSMUST00000189871.7
      Conserved Domains (1) summary
      sd00044
      Location:214 → 244
      HEAT; HEAT repeat [structural motif]

    2. XM_006516308.2 → XP_006516371.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

      Conserved Domains (2) summary
      PTZ00108
      Location:655 → 880
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:219 → 249
      HEAT; HEAT repeat [structural motif]

    3. XM_006516314.4 → XP_006516377.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

      Conserved Domains (1) summary
      sd00044
      Location:219 → 249
      HEAT; HEAT repeat [structural motif]

    4. XM_006516315.4 → XP_006516378.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

      Conserved Domains (1) summary
      sd00044
      Location:219 → 249
      HEAT; HEAT repeat [structural motif]

    5. XM_030246960.1 → XP_030102820.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:541 → 766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105 → 135
      HEAT; HEAT repeat [structural motif]

    6. XM_030246961.1 → XP_030102821.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:541 → 766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105 → 135
      HEAT; HEAT repeat [structural motif]

    7. XM_030246962.1 → XP_030102822.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Related
      ENSMUSP00000140874.2, ENSMUST00000187155.7
      Conserved Domains (2) summary
      PTZ00108
      Location:541 → 766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105 → 135
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_003950088.1 RNA Sequence

    2. XR_001780496.2 RNA Sequence

    3. XR_381552.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0Y0.2 GenPept UniProtKB/Swiss-Prot:Q8C0Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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