Srrt serrate, RNA effector molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Srrtprovided by RGD
Full Name: serrate, RNA effector moleculeprovided by RGD
Primary source: RGD:1591241
See related: Ensembl:ENSRNOG00000048277 AllianceGenome:RGD:1591241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07035787.1
Summary: Predicted to enable DNA binding activity; mRNA cap binding complex binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 265.5), Spleen (RPKM 189.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25027883..25042847)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19392578..19406098)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22457898..22471090)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA cap binding complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serrate RNA effector molecule homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427441.1 → NP_001414370.1 serrate RNA effector molecule homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

25027883..25042847

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090063.2 → XP_038945991.1 serrate RNA effector molecule homolog isoform X5

UniProtKB/TrEMBL

A0A8I6AM26

Related

ENSRNOP00000094934.1

Conserved Domains (2) summary

pfam04959
Location:645 → 842

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
XM_039090059.2 → XP_038945987.1 serrate RNA effector molecule homolog isoform X1

Conserved Domains (2) summary

pfam04959
Location:645 → 845

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
XM_039090060.2 → XP_038945988.1 serrate RNA effector molecule homolog isoform X2

Conserved Domains (2) summary

pfam04959
Location:645 → 838

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
XM_039090061.1 → XP_038945989.1 serrate RNA effector molecule homolog isoform X3

Conserved Domains (2) summary

pfam04959
Location:548 → 752

ARS2; Arsenite-resistance protein 2

pfam12066
Location:56 → 165

DUF3546; Domain of unknown function (DUF3546)
XM_039090062.2 → XP_038945990.1 serrate RNA effector molecule homolog isoform X4

Conserved Domains (2) summary

pfam04959
Location:418 → 622

ARS2; Arsenite-resistance protein 2

pfam12066
Location:1 → 35

DUF3546; Domain of unknown function (DUF3546)