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    Slc25a18 solute carrier family 25 member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681896, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slc25a18provided by RGD
    Official Full Name
    solute carrier family 25 member 18provided by RGD
    Primary source
    RGD:1590470
    See related
    Ensembl:ENSRNOG00000042731 AllianceGenome:RGD:1590470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Orthologous to human SLC25A18 (solute carrier family 25 member 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 124.1), Testes (RPKM 16.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155672939..155693549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154000808..154021373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153330069..153350447)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350753 Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene Bcl2-like 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
    2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105602

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-glutamate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial glutamate carrier 2
    Names
    GC-2
    glutamate carrier 2, mitochondrial
    glutamate/H(+) symporter 2
    solute carrier family 25 (glutamate carrier), member 18
    solute carrier family 25 (mitochondrial carrier), member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044280.2 → NP_001037745.2  mitochondrial glutamate carrier 2

      See identical proteins and their annotated locations for NP_001037745.2

      Status: VALIDATED

      Source sequence(s)
      BC094517, BG380364, CB726923
      UniProtKB/Swiss-Prot
      Q505J6
      UniProtKB/TrEMBL
      A0A8I5ZRK2, A6ILB0
      Related
      ENSRNOP00000015561.4, ENSRNOT00000015560.8
      Conserved Domains (1) summary
      pfam00153
      Location:9 → 102
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155672939..155693549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108348.2 → XP_038964276.1  mitochondrial glutamate carrier 2 isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:124 → 209
      Mito_carr; Mitochondrial carrier protein

    2. XM_063286684.1 → XP_063142754.1  mitochondrial glutamate carrier 2 isoform X1

      UniProtKB/Swiss-Prot
      Q505J6
      UniProtKB/TrEMBL
      A6ILB0

    3. XM_039108347.1 → XP_038964275.1  mitochondrial glutamate carrier 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRK2
      Related
      ENSRNOP00000081133.1, ENSRNOT00000113398.1
      Conserved Domains (1) summary
      pfam00153
      Location:176 → 261
      Mito_carr; Mitochondrial carrier protein

    4. XM_063286685.1 → XP_063142755.1  mitochondrial glutamate carrier 2 isoform X3

    5. XM_063286686.1 → XP_063142756.1  mitochondrial glutamate carrier 2 isoform X4

    RNA

    1. XR_010065706.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505J6.2 GenPept UniProtKB/Swiss-Prot:Q505J6

    Gene LinkOut

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