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    Pdcd2l programmed cell death 2-like [ Mus musculus (house mouse) ]

    Gene ID: 68079, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pdcd2lprovided by MGI
    Official Full Name
    programmed cell death 2-likeprovided by MGI
    Primary source
    MGI:MGI:1915329
    See related
    Ensembl:ENSMUSG00000002635 AllianceGenome:MGI:1915329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030457N17Rik
    Summary
    Predicted to be located in cytoplasm. Orthologous to human PDCD2L (programmed cell death 2 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 14.4), CNS E14 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 19.45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33883922..33896154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34184497..34196683, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 2 Neighboring gene STARR-seq mESC enhancer starr_18578 Neighboring gene STARR-seq mESC enhancer starr_18579 Neighboring gene STARR-seq mESC enhancer starr_18581 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10436 Neighboring gene glucose-6-phosphate isomerase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8163 Neighboring gene STARR-seq mESC enhancer starr_18586 Neighboring gene predicted gene 12762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development. Houston BJ, et al. G3 (Bethesda), 2020 Dec 3. PMID 33055224, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development.
      Title: Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144595

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    programmed cell death protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360710.1 → NP_001347639.1  programmed cell death protein 2-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1, that cause a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BX537302
      UniProtKB/TrEMBL
      F6SGV3
      Related
      ENSMUSP00000115874.2, ENSMUST00000148381.3
      Conserved Domains (1) summary
      pfam04194
      Location:242 → 276
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    2. NM_026549.4 → NP_080825.1  programmed cell death protein 2-like isoform 1

      See identical proteins and their annotated locations for NP_080825.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK151495, BX537302, CJ087550
      Consensus CDS
      CCDS21137.1
      UniProtKB/Swiss-Prot
      Q8C5N5, Q8R185, Q9D1M3
      Related
      ENSMUSP00000002710.4, ENSMUST00000002710.10
      Conserved Domains (1) summary
      pfam04194
      Location:242 → 356
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      33883922..33896154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153396.1 → XP_036009289.1  programmed cell death protein 2-like isoform X1

      UniProtKB/TrEMBL
      F6SGV3

    RNA

    1. XR_003946551.2 RNA Sequence

    2. XR_004934177.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5N5.1 GenPept UniProtKB/Swiss-Prot:Q8C5N5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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