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    Tmem19 transmembrane protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 67226, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Tmem19provided by MGI
    Official Full Name
    transmembrane protein 19provided by MGI
    Primary source
    MGI:MGI:1914476
    See related
    Ensembl:ENSMUSG00000069520 AllianceGenome:MGI:1914476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810428F02Rik
    Summary
    Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human TMEM19 (transmembrane protein 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 21.5), liver adult (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D2; 10 63.51 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115176644..115198406, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115340739..115362522, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3916 Neighboring gene STARR-positive B cell enhancer ABC_E6923 Neighboring gene predicted gene 10752 Neighboring gene predicted gene, 53632 Neighboring gene STARR-seq mESC enhancer starr_27937 Neighboring gene STARR-seq mESC enhancer starr_27939 Neighboring gene STARR-seq mESC enhancer starr_27942 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene predicted gene, 53633 Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene zinc finger, C3H1-type containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359470.1 → NP_001346399.1  transmembrane protein 19 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC153497, AK034298, AK138931, BB636118
      Consensus CDS
      CCDS88087.1
      UniProtKB/TrEMBL
      A0A1W2P7P6
      Related
      ENSMUSP00000151334.2, ENSMUST00000217887.2
      Conserved Domains (1) summary
      pfam01940
      Location:74 → 337
      DUF92; Integral membrane protein DUF92

    2. NM_001359471.2 → NP_001346400.1  transmembrane protein 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497
      Consensus CDS
      CCDS24178.1
      UniProtKB/Swiss-Prot
      Q3UU09, Q8BY23, Q8BZK7, Q91W52
      UniProtKB/TrEMBL
      A0A1W2P7P6
      Conserved Domains (1) summary
      pfam01940
      Location:59 → 322
      DUF92; Integral membrane protein DUF92

    3. NM_001359472.2 → NP_001346401.1  transmembrane protein 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497
      Consensus CDS
      CCDS24178.1
      UniProtKB/Swiss-Prot
      Q3UU09, Q8BY23, Q8BZK7, Q91W52
      UniProtKB/TrEMBL
      A0A1W2P7P6
      Related
      ENSMUSP00000151753.2, ENSMUST00000217884.2
      Conserved Domains (1) summary
      pfam01940
      Location:59 → 322
      DUF92; Integral membrane protein DUF92

    4. NM_001429443.1 → NP_001416372.1  transmembrane protein 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform 3.
      Source sequence(s)
      AC126943, AC153497

    5. NM_001429444.1 → NP_001416373.1  transmembrane protein 19 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497

    6. NM_001429445.1 → NP_001416374.1  transmembrane protein 19 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497

    7. NM_001429446.1 → NP_001416375.1  transmembrane protein 19 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform 4.
      Source sequence(s)
      AC126943, AC153497

    8. NM_001429447.1 → NP_001416376.1  transmembrane protein 19 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497

    9. NM_001429448.1 → NP_001416377.1  transmembrane protein 19 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC126943, AC153497

    10. NM_133683.5 → NP_598444.1  transmembrane protein 19 isoform 2

      See identical proteins and their annotated locations for NP_598444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform 2.
      Source sequence(s)
      AC126943, AC153497
      Consensus CDS
      CCDS24178.1
      UniProtKB/Swiss-Prot
      Q3UU09, Q8BY23, Q8BZK7, Q91W52
      UniProtKB/TrEMBL
      A0A1W2P7P6
      Related
      ENSMUSP00000089808.6, ENSMUST00000092170.7
      Conserved Domains (1) summary
      pfam01940
      Location:59 → 322
      DUF92; Integral membrane protein DUF92

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      115176644..115198406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513978.3 → XP_006514041.1  transmembrane protein 19 isoform X2

      See identical proteins and their annotated locations for XP_006514041.1

      UniProtKB/TrEMBL
      A0A1W2P7R5
      Related
      ENSMUSP00000151762.2, ENSMUST00000218731.2
      Conserved Domains (1) summary
      pfam01940
      Location:1 → 222
      DUF92; Integral membrane protein DUF92

    2. XM_006513977.2 → XP_006514040.1  transmembrane protein 19 isoform X2

      See identical proteins and their annotated locations for XP_006514040.1

      UniProtKB/TrEMBL
      A0A1W2P7R5
      Conserved Domains (1) summary
      pfam01940
      Location:1 → 222
      DUF92; Integral membrane protein DUF92

    3. XM_036155960.1 → XP_036011853.1  transmembrane protein 19 isoform X1

      UniProtKB/TrEMBL
      A0A1W2P7P6
      Conserved Domains (1) summary
      pfam01940
      Location:23 → 263
      DUF92; Integral membrane protein DUF92
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W52.1 GenPept UniProtKB/Swiss-Prot:Q91W52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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