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    Ogfod2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 66627, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ogfod2provided by MGI
    Official Full Name
    2-oxoglutarate and iron-dependent oxygenase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1913877
    See related
    Ensembl:ENSMUSG00000023707 AllianceGenome:MGI:1913877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300006G11Rik; 5730405M13Rik
    Summary
    Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity. Is expressed in embryo. Orthologous to human OGFOD2 (2-oxoglutarate and iron dependent oxygenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.6), colon adult (RPKM 17.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 63.39 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124250384..124253544)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124112321..124115482)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124525186-124525369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124529132-124529326 Neighboring gene ATP-binding cassette, sub-family B member 9 Neighboring gene STARR-positive B cell enhancer ABC_E432 Neighboring gene predicted gene 16001 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 4 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2 Neighboring gene predicted gene, 52788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Modzelewski AJ, et al. Cell, 2021 Oct 28. PMID 34644528, Free PMC Article
    2. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
    NP_001334407.1
    NP_001348411.1
    NP_001348412.1
    NP_079947.1
    XP_030110622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347478.3 → NP_001334407.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113474
      Consensus CDS
      CCDS84961.1
      UniProtKB/TrEMBL
      D3YU42
      Related
      ENSMUSP00000112701.2, ENSMUST00000119269.6

    2. NM_001361482.2 → NP_001348411.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113474
      Conserved Domains (1) summary
      smart00702
      Location:30 → 164
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. NM_001361483.2 → NP_001348412.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113474
      Conserved Domains (1) summary
      cl21496
      Location:122 → 234
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. NM_025671.4 → NP_079947.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_079947.1

      Status: VALIDATED

      Source sequence(s)
      AK018534, AU041636, BY126361
      Consensus CDS
      CCDS19672.1
      UniProtKB/Swiss-Prot
      Q78IV7, Q8BMW3, Q9CQ04
      Related
      ENSMUSP00000024470.7, ENSMUST00000024470.13
      Conserved Domains (1) summary
      smart00702
      Location:145 → 307
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124250384..124253544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254762.2 → XP_030110622.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      smart00702
      Location:89 → 223
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ04.1 GenPept UniProtKB/Swiss-Prot:Q9CQ04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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