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    SLPI secretory leukocyte peptidase inhibitor [ Homo sapiens (human) ]

    Gene ID: 6590, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SLPIprovided by HGNC
    Official Full Name
    secretory leukocyte peptidase inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:11092
    See related
    Ensembl:ENSG00000124107 MIM:107285; AllianceGenome:HGNC:11092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
    Summary
    This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLPI in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45252239..45254564, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46988133..46990454, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43880880..43883205, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372630 Neighboring gene semenogelin 2 Neighboring gene uncharacterized LOC124904913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12955 Neighboring gene matrilin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12956 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17946 Neighboring gene tRNA-Val (anticodon CAC) 14-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence. Nugteren S, et al. Sci Rep, 2022 Jul 16. PMID 35842496, Free PMC Article
    2. Levels of secretory leukocyte protease inhibitor expression in acute wounds. Lai J, et al. J Wound Care, 2022 Jul 1. PMID 35797252
    3. Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome. Dickey BL, et al. PLoS One, 2021. PMID 34214131, Free PMC Article
    4. Significance of secretory leukocyte peptidase inhibitor in pleural fluid for the diagnosis of benign asbestos pleural effusion. Kishimoto T, et al. Sci Rep, 2021 Jun 21. PMID 34155270, Free PMC Article
    5. Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis. Nugteren S, et al. Oncoimmunology, 2020 Oct 13. PMID 33101778, Free PMC Article

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications.
      Title: Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications.
    2. Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC.
      Title: Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.
    3. SLPI regulation and activity is altered in the nasal mucosa of smokers.
      Title: Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers.
    4. High Expression of secretory leukocyte protease inhibitor is associated with metastasis in colorectal cancer.
      Title: Expression of secretory leukocyte protease inhibitor detected by immunohistochemistry correlating with prognosis and metastasis in colorectal cancer.
    5. High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence.
      Title: High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence.
    6. Levels of secretory leukocyte protease inhibitor expression in acute wounds.
      Title: Levels of secretory leukocyte protease inhibitor expression in acute wounds.
    7. Modulation of HIV Replication in Monocyte-Derived Macrophages (MDM) by Host Antiviral Factors Secretory Leukocyte Protease Inhibitor and Serpin Family C Member 1 Induced by Steroid Hormones.
      Title: Modulation of HIV Replication in Monocyte-Derived Macrophages (MDM) by Host Antiviral Factors Secretory Leukocyte Protease Inhibitor and Serpin Family C Member 1 Induced by Steroid Hormones.
    8. The interaction of smoking habit, SLPI and AnxA2 in HPV associated head and neck and other cancers.
      Title: The interaction of smoking habit, SLPI and AnxA2 in HPV associated head and neck and other cancers.
    9. Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
      Title: Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
    10. Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
      Title: Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
    Submit: New GeneRIF Correction See all GeneRIFs (110)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The expression and production of secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, can be stimulated in oral epithelial cells through interactions with HIV-1 gp120 PubMed
    retropepsin gag-pol Secretory levels of secretory leukocyte peptidase inhibitor (SLPI) from HIV-1 infected patients is enhanced in saliva PubMed
    gag-pol Human secretory leukocyte protease inhibitor (hSLPI) inhibits HIV-1 infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antibacterial humoral response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in modulation of process of another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    antileukoproteinase
    Names
    HUSI-1
    WAP four-disulfide core domain protein 4
    mucus proteinase inhibitor
    protease inhibitor WAP4
    secretory leukocyte protease inhibitor (antileukoproteinase)
    seminal proteinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028137.1 RefSeqGene

      Range
      5002..7327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003064.4 → NP_003055.1  antileukoproteinase precursor

      See identical proteins and their annotated locations for NP_003055.1

      Status: REVIEWED

      Source sequence(s)
      BC020708
      Consensus CDS
      CCDS13347.1
      UniProtKB/Swiss-Prot
      B2R5H8, P03973, P07757
      Related
      ENSP00000342082.2, ENST00000338380.2
      Conserved Domains (2) summary
      smart00217
      Location:85 → 130
      WAP; Four-disulfide core domains
      pfam00095
      Location:31 → 73
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45252239..45254564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      46988133..46990454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03973.2 GenPept UniProtKB/Swiss-Prot:P03973

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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