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    RPL8 ribosomal protein L8 [ Homo sapiens (human) ]

    Gene ID: 6132, updated on 7-Apr-2024

    Summary

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    Official Symbol
    RPL8provided by HGNC
    Official Full Name
    ribosomal protein L8provided by HGNC
    Primary source
    HGNC:HGNC:10368
    See related
    Ensembl:ENSG00000161016 MIM:604177; AllianceGenome:HGNC:10368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L8; uL2
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 817.1), colon (RPKM 466.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q24.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144789769..144792390, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145963275..145965896, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146015154..146017775, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145990589-145991192 Neighboring gene uncharacterized LOC105375805 Neighboring gene Sharpr-MPRA regulatory region 4846 Neighboring gene Sharpr-MPRA regulatory region 10254 Neighboring gene zinc finger protein 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28103 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015453-146015954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015955-146016454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene microRNA 6850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene zinc finger protein 517 Neighboring gene uncharacterized LOC100130027 Neighboring gene hESC enhancers GRCh37_chr8:146052597-146053122 and GRCh37_chr8:146053123-146053648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146053649-146054174 Neighboring gene zinc finger protein 7 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene COMM domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing RPL8 inhibits the progression of hepatocellular carcinoma by down-regulating the mTORC1 signalling pathway. Sun T, et al. Hum Cell, 2023 Mar. PMID 36577883
    2. Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Liver Cancer. Fan S, et al. Comb Chem High Throughput Screen, 2023. PMID 36017842
    3. Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Wang C, et al. Acta Crystallogr D Biol Crystallogr, 2015 Sep. PMID 26327385, Free PMC Article
    4. Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies. Uhlein M, et al. Biochem J, 1998 Apr 15. PMID 9531480, Free PMC Article
    5. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. Hanes J, et al. Biochem Biophys Res Commun, 1993 Dec 30. PMID 7506540

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Liver Cancer.
      Title: Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Liver Cancer.
    2. Silencing RPL8 inhibits the progression of hepatocellular carcinoma by down-regulating the mTORC1 signalling pathway.
      Title: Silencing RPL8 inhibits the progression of hepatocellular carcinoma by down-regulating the mTORC1 signalling pathway.
    3. Report dysregulated expression of RPL8 in disc degeneration.
      Title: Dysregulated COL3A1 and RPL8, RPS16, and RPS23 in Disc Degeneration Revealed by Bioinformatics Methods.
    4. confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8
      Title: Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.
    5. gain of RPL8 is associated with good response to chemotherapy in conventional osteosarcomas.
      Title: Molecular characterization of the response to chemotherapy in conventional osteosarcomas: predictive value of HSD17B10 and IFITM2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL2
    Names
    60S ribosomal protein L8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000973.5 → NP_000964.1  large ribosomal subunit protein uL2

      See identical proteins and their annotated locations for NP_000964.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC093064
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      A8K094, D3DWN2, P25120, P62917, Q567Q7, Q969V7, Q9BWQ9
      UniProtKB/TrEMBL
      E9PKU4
      Related
      ENSP00000262584.3, ENST00000262584.7
      Conserved Domains (1) summary
      cl40667
      Location:1 → 254
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

    2. NM_001317771.2 → NP_001304700.1  large ribosomal subunit protein uL2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AF235103, BM783910, BQ929065, CB128790
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      A8K094, D3DWN2, P25120, P62917, Q567Q7, Q969V7, Q9BWQ9
      UniProtKB/TrEMBL
      E9PKU4
      Conserved Domains (1) summary
      cl40667
      Location:1 → 254
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

    3. NM_001317782.2 → NP_001304711.1  large ribosomal subunit protein uL2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) retains an intron in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AF235103, BC030151, BG480561, CB128790
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      A8K094, D3DWN2, P25120, P62917, Q567Q7, Q969V7, Q9BWQ9
      UniProtKB/TrEMBL
      E9PKU4
      Related
      ENSP00000433464.2, ENST00000528957.6
      Conserved Domains (1) summary
      cl40667
      Location:1 → 254
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

    4. NM_033301.3 → NP_150644.1  large ribosomal subunit protein uL2

      See identical proteins and their annotated locations for NP_150644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AF235103, BC012197, BC030151, CB128790
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      A8K094, D3DWN2, P25120, P62917, Q567Q7, Q969V7, Q9BWQ9
      UniProtKB/TrEMBL
      E9PKU4
      Related
      ENSP00000378378.2, ENST00000394920.6
      Conserved Domains (1) summary
      cl40667
      Location:1 → 254
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144789769..144792390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145963275..145965896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62917.2 GenPept UniProtKB/Swiss-Prot:P62917

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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