wdr4 WD repeat domain 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr4provided by ZNC
Official Full Name: WD repeat domain 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-060810-10
See related: Ensembl:ENSDARG00000090581 AllianceGenome:ZFIN:ZDB-GENE-060810-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6900357; si:ch211-140m22.6
Summary: Predicted to contribute to tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within RNA (guanine-N7)-methylation and tRNA processing. Predicted to be part of tRNA methyltransferase complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (19477198..19489264, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (19666329..19678395, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4

Names: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126435.2 → NP_001119907.2 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4

Status: VALIDATED

Source sequence(s)

EH546277, FP017279

UniProtKB/Swiss-Prot

A4IGH4, B0UXG2

UniProtKB/TrEMBL

A0A8M1NGR4, E7EZ59

Related

ENSDARP00000109363.1, ENSDART00000122894.3

Conserved Domains (3) summary

COG2319
Location:46 → 292

WD40; WD40 repeat [General function prediction only]

sd00039
Location:106 → 144

7WD40; WD40 repeat [structural motif]

cl02567
Location:61 → 260

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...