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    dlgap1a discs, large (Drosophila) homolog-associated protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 569898, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dlgap1aprovided by ZNC
    Official Full Name
    discs, large (Drosophila) homolog-associated protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-580
    See related
    Ensembl:ENSDARG00000014280 AllianceGenome:ZFIN:ZDB-GENE-030616-580
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dlgap1; si:zc142h2.3
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in plasma membrane and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic specialization. Is expressed in central nervous system; olfactory bulb; and olfactory placode. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (29491321..29693404)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (29507853..29710164)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cadherin 18, type 2a Neighboring gene carbonic anhydrase Neighboring gene si:dkey-188g12.1 Neighboring gene antisense RNA gene 1666 Neighboring gene pancreas associated transcription factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disks large-associated protein 1
    Names
    DAP-1
    discs, large homolog-associated protein 1
    discs, large-associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202455.1 → NP_001189384.1  disks large-associated protein 1

      See identical proteins and their annotated locations for NP_001189384.1

      Status: INFERRED

      Source sequence(s)
      AL845362
      UniProtKB/Swiss-Prot
      Q7ZYZ6
      Related
      ENSDARP00000113100.1, ENSDART00000131271.2
      Conserved Domains (1) summary
      pfam03359
      Location:691 → 999
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      29491321..29693404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481046.1 → XP_021336721.1  disks large-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QKM8
      Conserved Domains (1) summary
      pfam03359
      Location:667 → 929
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. XM_017358897.2 → XP_017214386.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z2F8

    3. XM_009298580.3 → XP_009296855.1  disks large-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AXB6
      Conserved Domains (1) summary
      pfam03359
      Location:632 → 962
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. XM_005163439.4 → XP_005163496.1  disks large-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BAI9
      Conserved Domains (1) summary
      pfam03359
      Location:667 → 996
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. XM_009298579.3 → XP_009296854.1  disks large-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8PYA5, A0A8M3B0B5
      Related
      ENSDARP00000144876.1, ENSDART00000181774.1
      Conserved Domains (1) summary
      pfam03359
      Location:667 → 997
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. XM_017358896.2 → XP_017214385.1  disks large-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z994
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZYZ6.2 GenPept UniProtKB/Swiss-Prot:Q7ZYZ6

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