fzd3a frizzled class receptor 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd3aprovided by ZNC
Official Full Name: frizzled class receptor 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-225
See related: Ensembl:ENSDARG00000021664 AllianceGenome:ZFIN:ZDB-GENE-990415-225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz9; fzd3; zg09
Summary: Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Acts upstream of or within anterior/posterior axon guidance; commissural neuron axon guidance; and facial nucleus development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; neural plate; neural tube; neurons; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (35208851..35246212, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (35305972..35343317, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 and Scribble both prior to and after midline crossing; experiments establish CoPA axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.
Title: Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance.
these results revealed that wnt8b and fzd3a act in the same genetic pathway to pattern the commissural plate, thereby indirectly regulating the crossing of axons across the rostral midline in the embryonic forebrain of zebrafish.
Title: Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish.
These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.
Title: Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon.

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General gene information

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Markers

fk49a04.x1 (e-PCR)
- UniSTS:201070

U49413 (e-PCR)
- UniSTS:187067

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within commissural neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within facial nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: frizzled-3; frizzled-3a

Names: frizzled 9; frizzled homolog 3; frizzled homolog 3a; fz3a; off-limits; olt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042761.2 → NP_001036226.1 frizzled-3a precursor

See identical proteins and their annotated locations for NP_001036226.1

Status: PROVISIONAL

Source sequence(s)

DQ200953

UniProtKB/TrEMBL

A0EJF7, Q5TZ38

Related

ENSDARP00000084982.5, ENSDART00000090549.8

Conserved Domains (2) summary

cd07449
Location:26 → 152

CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor

cd15033
Location:194 → 513

7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

35208851..35246212 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160748.4 → XP_005160805.1 frizzled-3 isoform X1

UniProtKB/TrEMBL

A0A8M2B7P5

Conserved Domains (2) summary

cd07449
Location:26 → 152

CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor

pfam01534
Location:195 → 513

Frizzled; Frizzled/Smoothened family membrane region