tut1 terminal uridylyl transferase 1, U6 snRNA-specific [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tut1provided by ZNC
Official Full Name: terminal uridylyl transferase 1, U6 snRNA-specificprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050706-68
See related: Ensembl:ENSDARG00000057321 AllianceGenome:ZFIN:ZDB-GENE-050706-68
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112254
Summary: Predicted to enable RNA adenylyltransferase activity; RNA uridylyltransferase activity; and mRNA 3'-UTR binding activity. Predicted to be involved in mRNA polyadenylation; pre-mRNA cleavage required for polyadenylation; and snRNA processing. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleolus. Predicted to be active in nuclear speck. Is expressed in head; ovary; and testis. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (10337676..10351959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (10299833..10314116, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables RNA uridylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in snRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: speckle targeted PIP5K1A-regulated poly(A) polymerase

Names: RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; star-PAP

NP_001025359.1

EC 2.7.7.19

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030188.1 → NP_001025359.1 speckle targeted PIP5K1A-regulated poly(A) polymerase

See identical proteins and their annotated locations for NP_001025359.1

Status: PROVISIONAL

Source sequence(s)

BC098614

UniProtKB/Swiss-Prot

Q4KMD7

Related

ENSDARP00000074395.4, ENSDART00000079945.5

Conserved Domains (6) summary

cd05402
Location:179 → 327

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00451
Location:11 → 38

ZnF_U1; U1-like zinc finger

COG0724
Location:47 → 134

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12279
Location:52 → 125

RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins

sd00020
Location:16 → 38

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam03828
Location:421 → 495

PAP_assoc; Cid1 family poly A polymerase