rgs6 regulator of G protein signaling 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs6provided by ZNC
Official Full Name: regulator of G protein signaling 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-31
See related: Ensembl:ENSDARG00000015627 AllianceGenome:ZFIN:ZDB-GENE-030131-31
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hm:zeh0300; si:ch211-268e23.2
Summary: Predicted to enable GTPase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; intracellular signal transduction; and negative regulation of signal transduction. Is expressed in nervous system and trigeminal placode. Orthologous to human RGS6 (regulator of G protein signaling 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (28511941..28638864, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (28609062..28735985, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach.
Title: Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regulator of G-protein signaling 6

Names: regulator of G-protein signalling 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035263.2 → NP_001030340.1 regulator of G-protein signaling 6

See identical proteins and their annotated locations for NP_001030340.1

Status: VALIDATED

Source sequence(s)

BX255881, BX569801

UniProtKB/TrEMBL

A0A8M1N7V3, F1R7H0, Q38JL1

Related

ENSDARP00000145833.1, ENSDART00000184779.1

Conserved Domains (3) summary

smart00224
Location:257 → 318

GGL; G protein gamma subunit-like motifs

cd08737
Location:327 → 451

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 118

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...