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    rnf19b ring finger protein 19B [ Danio rerio (zebrafish) ]

    Gene ID: 562396, updated on 27-Mar-2024

    Summary

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    Official Symbol
    rnf19bprovided by ZNC
    Official Full Name
    ring finger protein 19Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-281
    See related
    Ensembl:ENSDARG00000060926 AllianceGenome:ZFIN:ZDB-GENE-060503-281
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:rp71-45k5.9
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35378908..35416025, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35792464..35828885, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene microtubule actin crosslinking factor 1a Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene adenylate kinase 2 Neighboring gene anillin, actin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF19B
    NP_001189369.1
    XP_005159717.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202440.1 → NP_001189369.1  E3 ubiquitin-protein ligase RNF19B

      See identical proteins and their annotated locations for NP_001189369.1

      Status: INFERRED

      Source sequence(s)
      CR753876
      UniProtKB/Swiss-Prot
      Q1L8L6
      Related
      ENSDARP00000116147.1, ENSDART00000148080.2
      Conserved Domains (3) summary
      smart00647
      Location:174 → 239
      IBR; In Between Ring fingers
      pfam01485
      Location:269 → 307
      IBR; IBR domain, a half RING-finger domain
      pfam01925
      Location:329 → 421
      TauE; Sulfite exporter TauE/SafE

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35378908..35416025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159660.4 → XP_005159717.1  E3 ubiquitin-protein ligase RNF19B isoform X1

      See identical proteins and their annotated locations for XP_005159717.1

      UniProtKB/Swiss-Prot
      Q1L8L6
      Conserved Domains (3) summary
      smart00647
      Location:174 → 239
      IBR; In Between Ring fingers
      pfam01485
      Location:269 → 307
      IBR; IBR domain, a half RING-finger domain
      pfam01925
      Location:329 → 421
      TauE; Sulfite exporter TauE/SafE
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1L8L6.2 GenPept UniProtKB/Swiss-Prot:Q1L8L6

    Gene LinkOut

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