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    usp49 ubiquitin specific peptidase 49 [ Danio rerio (zebrafish) ]

    Gene ID: 559473, updated on 11-Apr-2024

    Summary

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    Official Symbol
    usp49provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 49provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-484
    See related
    Ensembl:ENSDARG00000000229 AllianceGenome:ZFIN:ZDB-GENE-050208-484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:rp71-11b17.7
    Summary
    Predicted to enable thiol-dependent deubiquitinase and zinc ion binding activity. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (564638..581689)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (526915..544158)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene mediator complex subunit 20 Neighboring gene bystin-like Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene cyclin dependent kinase inhibitor 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 49
    NP_001038361.1
    XP_005168329.1
    XP_009294033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044896.1 → NP_001038361.1  ubiquitin carboxyl-terminal hydrolase 49

      See identical proteins and their annotated locations for NP_001038361.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645789
      UniProtKB/TrEMBL
      A0A0R4IEA5, Q1MTK1
      Related
      ENSDARP00000036071.4, ENSDART00000037069.5
      Conserved Domains (3) summary
      cl02553
      Location:266 → 645
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:264 → 644
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      564638..581689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168272.4 → XP_005168329.1  ubiquitin carboxyl-terminal hydrolase 49 isoform X1

      See identical proteins and their annotated locations for XP_005168329.1

      UniProtKB/TrEMBL
      A0A0R4IEA5, Q1MTK1
      Conserved Domains (3) summary
      cl02553
      Location:266 → 645
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:264 → 644
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. XM_009295758.3 → XP_009294033.1  ubiquitin carboxyl-terminal hydrolase 49 isoform X1

      See identical proteins and their annotated locations for XP_009294033.1

      UniProtKB/TrEMBL
      A0A0R4IEA5, Q1MTK1
      Related
      ENSDARP00000133726.1, ENSDART00000171036.2
      Conserved Domains (3) summary
      cl02553
      Location:266 → 645
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:264 → 644
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein Strain
    Heading Accession and Version

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