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    mapre3a microtubule-associated protein, RP/EB family, member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 559217, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mapre3aprovided by ZNC
    Official Full Name
    microtubule-associated protein, RP/EB family, member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-88
    See related
    Ensembl:ENSDARG00000020231 AllianceGenome:ZFIN:ZDB-GENE-050913-88
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:114065
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (36866008..36896615, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (36919459..36949012, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene myosin VIb Neighboring gene SUMO specific peptidase 6b Neighboring gene dihydropyrimidinase like 5a Neighboring gene DNA (cytosine-5-)-methyltransferase 3 alpha b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Marchal GA, et al. Circ Res, 2021 Jul 23. PMID 34092082, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC114065

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 3a; microtubule-associated protein, RP/EB family, member 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030127.1 → NP_001025298.1  microtubule-associated protein RP/EB family member 3a

      See identical proteins and their annotated locations for NP_001025298.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097127
      UniProtKB/TrEMBL
      A0A8M1N7E3, Q4V903
      Related
      ENSDARP00000045286.6, ENSDART00000045287.7
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 114
      CH; Calponin homology (CH) domain
      pfam03271
      Location:198 → 235
      EB1; EB1-like C-terminal motif

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      36866008..36896615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158846.4 → XP_005158903.1  microtubule-associated protein, RP/EB family, member 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5B2
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 114
      CH; Calponin homology (CH) domain
      pfam03271
      Location:212 → 249
      EB1; EB1-like C-terminal motif

    2. XM_009293205.2 → XP_009291480.1  microtubule-associated protein, RP/EB family, member 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AUH2
      Conserved Domains (1) summary
      pfam00307
      Location:16 → 114
      CH; Calponin homology (CH) domain
    Nucleotide Protein
    Heading Accession and Version

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