dmrt2b doublesex and mab-3 related transcription factor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dmrt2bprovided by ZNC
Official Full Name: doublesex and mab-3 related transcription factor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080813-1
See related: Ensembl:ENSDARG00000070013 AllianceGenome:ZFIN:ZDB-GENE-080813-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within chordate embryonic development; determination of left/right symmetry; and muscle cell development. Predicted to be active in nucleus. Is expressed in digestive system; muscle; ovary; and somite. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (34214067..34220397, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (34230684..34237014, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment
Title: Fish-specific duplicated dmrt2b contributes to a divergent function through Hedgehog pathway and maintains left-right asymmetry establishment function.
Cloning, expression and synteny analysis of a duplicated copy of zebrafish Dmrt2a gene, the Dmrt2b which is fish specific, whereas Dmrt2a exists in all vertebrates.
Title: Fish specific duplication of Dmrt2: characterization of zebrafish Dmrt2b.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079976.1 → NP_001073445.1 doublesex- and mab-3-related transcription factor 2b

See identical proteins and their annotated locations for NP_001073445.1

Status: PROVISIONAL

Source sequence(s)

DQ307066

UniProtKB/TrEMBL

A0SDZ6

Related

ENSDARP00000093167.3, ENSDART00000102391.4

Conserved Domains (2) summary

pfam00751
Location:46 → 92

DM; DM DNA binding domain

pfam15290
Location:105 → 189

Syntaphilin; Golgi-localized syntaxin-1-binding clamp