U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    cnksr2b connector enhancer of kinase suppressor of Ras 2b [ Danio rerio (zebrafish) ]

    Gene ID: 558834, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cnksr2bprovided by ZNC
    Official Full Name
    connector enhancer of kinase suppressor of Ras 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8048
    See related
    Ensembl:ENSDARG00000073707 AllianceGenome:ZFIN:ZDB-GENE-030131-8048
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj48e09; wu:fj48e09; si:dkey-92k1.12
    Summary
    Predicted to act upstream of or within regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (25425161..25523018, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (25388556..25486433, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene spermine synthase Neighboring gene uncharacterized LOC101886303 Neighboring gene si:dkey-17e16.9 Neighboring gene NLR family, CARD domain containing 3-like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression pattern of the small muscle protein, X-linked (smpx) gene during zebrafish embryonic and larval developmental stages. Ghilardi A, et al. Gene Expr Patterns, 2020 Jun. PMID 32197943
    2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    connector enhancer of kinase suppressor of ras 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      25425161..25523018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682101.7 → XP_687193.3  connector enhancer of kinase suppressor of ras 2 isoform X2

      UniProtKB/TrEMBL
      A0A8N7UV27, E7FAZ0
      Related
      ENSDARP00000103132.3, ENSDART00000110923.4
      Conserved Domains (7) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:223 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:549 → 661
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:563 → 659
      PH; PH domain
      pfam06663
      Location:341 → 469
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

    2. XM_009295430.3 → XP_009293705.1  connector enhancer of kinase suppressor of ras 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AM98
      Conserved Domains (7) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:229 → 300
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:555 → 667
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:569 → 665
      PH; PH domain
      pfam06663
      Location:347 → 475
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 182
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools